J Gen Virol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Billecocq, A.
Right arrow Articles by Bouloy, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Billecocq, A.
Right arrow Articles by Bouloy, M.
Agricola
Right arrow Articles by Billecocq, A.
Right arrow Articles by Bouloy, M.
Journal of General Virology (2000), 81, 2161-2166.
© 2000 Society for General Microbiology

Animal: RNA Viruses

Pathogen-specific resistance to Rift Valley fever virus infection is induced in mosquito cells by expression of the recombinant nucleoprotein but not NSs non-structural protein sequences

A. Billecocq1, M. Vazeille-Falcoz2, F. Rodhain2 and M. Bouloy1

Groupe des Bunyaviridés1 and Unité d’écologie des systèmes vectoriels2, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France

Author for correspondence: Michèle Bouloy. Fax +33 1 40 61 31 51. e-mail mbouloy{at}pasteur.fr

Rift Valley fever virus (RVFV) is an arbovirus of the Bunyaviridae family, causing recurrent disease outbreaks in Africa. Natural vertebrate hosts include cattle and humans. Several mosquito species belonging to the Aedes and Culex generaact as vectors of this phlebovirus. To test whether pathogen-derived resistance against RVFV could be induced by expressing genomic sequences in mosquito cells, as has been shown for La Crosse and dengue 2 viruses, we generated various recombinant Semliki Forest viruses expressing the S segment (or its genes) in the genomic or antigenomic sense. Expression of the N but not the NSs gene interfered with the production of RVFV in mosquito cells and this phenomenon was RNA- but not protein-dependent. These results raise questions on the molecular mechanisms involved in virus resistance.




This article has been cited by other articles:


Home page
 J. Virol.Home page
S. Garcia, A. Billecocq, J.-M. Crance, U. Munderloh, D. Garin, and M. Bouloy
Nairovirus RNA Sequences Expressed by a Semliki Forest Virus Replicon Induce RNA Interference in Tick Cells
J. Virol., July 15, 2005; 79(14): 8942 - 8947.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
I. Andersson, L. Bladh, M. Mousavi-Jazi, K.-E. Magnusson, A. Lundkvist, O. Haller, and A. Mirazimi
Human MxA Protein Inhibits the Replication of Crimean-Congo Hemorrhagic Fever Virus
J. Virol., April 15, 2004; 78(8): 4323 - 4329.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
T. Geib, C. Sauder, S. Venturelli, C. Hassler, P. Staeheli, and M. Schwemmle
Selective Virus Resistance Conferred by Expression of Borna Disease Virus Nucleocapsid Components
J. Virol., April 1, 2003; 77(7): 4283 - 4290.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
H. Li, W. X. Li, and S. W. Ding
Induction and Suppression of RNA Silencing by an Animal Virus
Science, May 17, 2002; 296(5571): 1319 - 1321.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2000 by the Society for General Microbiology.