| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Animal: DNA Viruses |
Medical Research Council Virology Unit, Church Street, Glasgow G11 5JR, UK1
Author for correspondence: Chris Preston. Fax +44 141 337 2236. e-mail c.preston{at}vir.gla.ac.uk
Previous studies have shown that infection of human fibroblasts with human cytomegalovirus (HCMV) results in activation of cellular interferon-responsive gene expression. We demonstrate here that infection of human fibroblasts with herpes simplex virus type 1 (HSV-1) in the absence of de novo protein synthesis also induces the expression of interferon-responsive genes. Five genes tested (encoding ISG54, IFI56, ISG15, 9-27 and MxA) were activated by infection with HSV-1, although the degree of response varied between the individual genes. HSV-1 was a less efficient inducer than HCMV. The effect was a consequence of binding of the virus particle to the cell surface or of the presence of virion components within the infected cell. Induction was mediated by a pathway other than the mechanism through which interferon-
mediates its effects on cellular gene expression.
This article has been cited by other articles:
|
|
 |
|
  T. Peng, J. Zhu, A. Klock, K. Phasouk, M.-L. Huang, D. M. Koelle, A. Wald, and L. Corey Evasion of the Mucosal Innate Immune System by Herpes Simplex Virus Type 2 J. Virol., December 1, 2009; 83(23): 12559 - 12568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett and A. Orr Herpes Simplex Virus Type 1 Regulatory Protein ICP0 Aids Infection in Cells with a Preinduced Interferon Response but Does Not Impede Interferon-Induced Gene Induction J. Virol., May 15, 2009; 83(10): 4978 - 4983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Daubeuf, D. Singh, Y. Tan, H. Liu, H. J. Federoff, W. J. Bowers, and K. Tolba HSV ICP0 recruits USP7 to modulate TLR-mediated innate response Blood, April 2, 2009; 113(14): 3264 - 3275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Verpooten, Y. Ma, S. Hou, Z. Yan, and B. He Control of TANK-binding Kinase 1-mediated Signaling by the {gamma}134.5 Protein of Herpes Simplex Virus 1 J. Biol. Chem., January 9, 2009; 284(2): 1097 - 1105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett, D. F. Young, R. E. Randall, and A. Orr STAT-1- and IRF-3-Dependent Pathways Are Not Essential for Repression of ICP0-Null Mutant Herpes Simplex Virus Type 1 in Human Fibroblasts J. Virol., September 1, 2008; 82(17): 8871 - 8881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Le Tortorec, H. Denis, A-P. Satie, J-J. Patard, A. Ruffault, B. Jegou, and N. Dejucq-Rainsford Antiviral responses of human Leydig cells to mumps virus infection or poly I:C stimulation Hum. Reprod., September 1, 2008; 23(9): 2095 - 2103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Peng, J. Zhu, Y. Hwangbo, L. Corey, and R. E. Bumgarner Independent and Cooperative Antiviral Actions of Beta Interferon and Gamma Interferon against Herpes Simplex Virus Replication in Primary Human Fibroblasts J. Virol., February 15, 2008; 82(4): 1934 - 1945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Paladino, D. T. Cummings, R. S. Noyce, and K. L. Mossman The IFN-Independent Response to Virus Particle Entry Provides a First Line of Antiviral Defense That Is Independent of TLRs and Retinoic Acid-Inducible Gene I J. Immunol., December 1, 2006; 177(11): 8008 - 8016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Barreca and P. O'Hare Characterization of a Potent Refractory State and Persistence of Herpes Simplex Virus 1 in Cell Culture J. Virol., September 15, 2006; 80(18): 9171 - 9180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Sanfilippo and J. A. Blaho ICP0 Gene Expression Is a Herpes Simplex Virus Type 1 Apoptotic Trigger J. Virol., July 15, 2006; 80(14): 6810 - 6821. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Y. Wong, Y. F. Pung, N. S.-K. Sze, and K.-C. Chin HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets PNAS, July 11, 2006; 103(28): 10735 - 10740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Noyce, S. E. Collins, and K. L. Mossman Identification of a Novel Pathway Essential for the Immediate-Early, Interferon-Independent Antiviral Response to Enveloped Virions J. Virol., January 1, 2006; 80(1): 226 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Lenschow, N. V. Giannakopoulos, L. J. Gunn, C. Johnston, A. K. O'Guin, R. E. Schmidt, B. Levine, and H. W. Virgin IV Identification of Interferon-Stimulated Gene 15 as an Antiviral Molecule during Sindbis Virus Infection In Vivo J. Virol., November 15, 2005; 79(22): 13974 - 13983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. K. Harvey, E. G. Romanowski, K. A. Yates, and Y. J. Gordon Adenovirus-Directed Ocular Innate Immunity: The Role of Conjunctival Defensin-like Chemokines (IP-10, I-TAC) and Phagocytic Human Defensin-{alpha} Invest. Ophthalmol. Vis. Sci., October 1, 2005; 46(10): 3657 - 3665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Hahn, L. E. Huye, S. Ning, J. Webster-Cyriaque, and J. S. Pagano Interferon Regulatory Factor 7 Is Negatively Regulated by the Epstein-Barr Virus Immediate-Early Gene, BZLF-1 J. Virol., August 1, 2005; 79(15): 10040 - 10052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-L. Hsu, H. A. Saffran, and J. R. Smiley Herpes Simplex Virus Infection Stabilizes Cellular IEX-1 mRNA J. Virol., April 1, 2005; 79(7): 4090 - 4098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mulvey, V. Camarena, and I. Mohr Full Resistance of Herpes Simplex Virus Type 1-Infected Primary Human Cells to Alpha Interferon Requires both the Us11 and {gamma}134.5 Gene Products J. Virol., September 15, 2004; 78(18): 10193 - 10196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Melroe, N. A. DeLuca, and D. M. Knipe Herpes Simplex Virus 1 Has Multiple Mechanisms for Blocking Virus-Induced Interferon Production J. Virol., August 15, 2004; 78(16): 8411 - 8420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Barreca and P. O'Hare Suppression of Herpes Simplex Virus 1 in MDBK Cells via the Interferon Pathway J. Virol., August 15, 2004; 78(16): 8641 - 8653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Yokota, N. Yokosawa, T. Okabayashi, T. Suzutani, S. Miura, K. Jimbow, and N. Fujii Induction of Suppressor of Cytokine Signaling-3 by Herpes Simplex Virus Type 1 Contributes to Inhibition of the Interferon Signaling Pathway J. Virol., June 15, 2004; 78(12): 6282 - 6286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Adams, K. Besken, C. Oberdorfer, C. R. MacKenzie, O. Takikawa, and W. Daubener Role of Indoleamine-2,3-Dioxygenase in Alpha/Beta and Gamma Interferon-Mediated Antiviral Effects against Herpes Simplex Virus Infections J. Virol., March 1, 2004; 78(5): 2632 - 2636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lin, R. S. Noyce, S. E. Collins, R. D. Everett, and K. L. Mossman The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-Mediated Activation of Interferon-Stimulated Genes J. Virol., February 15, 2004; 78(4): 1675 - 1684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Collins, R. S. Noyce, and K. L. Mossman Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication J. Virol., February 15, 2004; 78(4): 1706 - 1717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett, C. Boutell, and A. Orr Phenotype of a Herpes Simplex Virus Type 1 Mutant That Fails To Express Immediate-Early Regulatory Protein ICP0 J. Virol., February 15, 2004; 78(4): 1763 - 1774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Smiley Herpes Simplex Virus Virion Host Shutoff Protein: Immune Evasion Mediated by a Viral RNase? J. Virol., February 1, 2004; 78(3): 1063 - 1068. [Full Text] [PDF]
|
|
|
|
|
|
C. M. Sanfilippo, F. N. W. Chirimuuta, and J. A. Blaho Herpes Simplex Virus Type 1 Immediate-Early Gene Expression Is Required for the Induction of Apoptosis in Human Epithelial HEp-2 Cells J. Virol., January 1, 2004; 78(1): 224 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Murphy, R. J. Duerst, T. J. Smith, and L. A. Morrison Herpes Simplex Virus Type 2 Virion Host Shutoff Protein Regulates Alpha/Beta Interferon but Not Adaptive Immune Responses during Primary Infection In Vivo J. Virol., September 1, 2003; 77(17): 9337 - 9345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Goodkin, A. T. Ting, and J. A. Blaho NF-{kappa}B Is Required for Apoptosis Prevention during Herpes Simplex Virus Type 1 Infection J. Virol., July 1, 2003; 77(13): 7261 - 7280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. X. Zhu and Y. Yuan The ORF45 Protein of Kaposi's Sarcoma-Associated Herpesvirus Is Associated with Purified Virions J. Virol., April 1, 2003; 77(7): 4221 - 4230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Grandvaux, M. J. Servant, B. tenOever, G. C. Sen, S. Balachandran, G. N. Barber, R. Lin, and J. Hiscott Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes J. Virol., June 1, 2002; 76(11): 5532 - 5539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Scott, S. Malcomber, and P. O'Hare Nuclear Translocation and Activation of the Transcription Factor NFAT Is Blocked by Herpes Simplex Virus Infection J. Virol., October 15, 2001; 75(20): 9955 - 9965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Preston, A. N. Harman, and M. J. Nicholl Activation of Interferon Response Factor-3 in Human Cells Infected with Herpes Simplex Virus Type 1 or Human Cytomegalovirus J. Virol., October 1, 2001; 75(19): 8909 - 8916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Mossman, P. F. Macgregor, J. J. Rozmus, A. B. Goryachev, A. M. Edwards, and J. R. Smiley Herpes Simplex Virus Triggers and Then Disarms a Host Antiviral Response J. Virol., January 15, 2001; 75(2): 750 - 758. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
