| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Animal: RNA Viruses |
Epidemiología y Bioestadística1 and Hepatología-IMD2, Fundació Clínic, IDIBAPS, Hospital Clínic, Universidad de Barcelona, Villaroel 170, 08036 Barcelona, Spain
Centro de Investigaçao en Saude da Manhiça, INS-Ministerio da Saude, Mozambique3
Servicio de Virología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain4
Author for correspondence: Juan-Carlos Saiz. Fax +34 93 4515522. e-mail jcsaiz{at}medicina.ub.es
Respiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infection in children and vulnerable adults, but little is known regarding RSV infection in Africa. In this report, a recent RSV outbreak in Mozambique was studied and results showed that 275 of 3192 (8·6%) nasopharyngeal aspirates tested were RSV-positive by ELISA. RSV presents two antigenic groups (A and B) with a high genetic and antigenic variability between and within them. Analysis by a new RFLP assay of RT–PCR amplified N protein gene products showed a higher prevalence of group B RSV than that of group A (85% versus 15%). However, genetic variability of the G protein gene was higher among group A RSV strains. The frequency and pattern of glycosylation sites were also quite different between both groups. In addition, two different phylogenetic clusters of Mozambican viruses were found within each group, but only sequences from cluster B-I were relatively distinct from previously described isolates. The implications of such differences in the antigenic and immunogenic characteristics of each group are discussed.
This article has been cited by other articles:
|
|
 |
|
  S. Parveen, W. M. Sullender, K. Fowler, E. J. Lefkowitz, S. K. Kapoor, and S. Broor Genetic variability in the g protein gene of group a and B respiratory syncytial viruses from India. J. Clin. Microbiol., September 1, 2006; 44(9): 3055 - 3064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Trento, M. Viegas, M. Galiano, C. Videla, G. Carballal, A. S. Mistchenko, and J. A. Melero Natural History of Human Respiratory Syncytial Virus Inferred from Phylogenetic Analysis of the Attachment (G) Glycoprotein with a 60-Nucleotide Duplication J. Virol., January 15, 2006; 80(2): 975 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. T. Zlateva, P. Lemey, E. Moes, A.-M. Vandamme, and M. Van Ranst Genetic Variability and Molecular Evolution of the Human Respiratory Syncytial Virus Subgroup B Attachment G Protein J. Virol., July 15, 2005; 79(14): 9157 - 9167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Galiano, C. Palomo, C. M. Videla, J. Arbiza, J. A. Melero, and G. Carballal Genetic and Antigenic Variability of Human Respiratory Syncytial Virus (Groups A and B) Isolated over Seven Consecutive Seasons in Argentina (1995 to 2001) J. Clin. Microbiol., May 1, 2005; 43(5): 2266 - 2273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Elliott, K. S. Pryharski, Q. Yu, C. L. Parks, T. S. Laughlin, C. K. Gupta, R. A. Lerch, V. B. Randolph, N. A. LaPierre, K. M. H. Dack, et al. Recombinant Respiratory Syncytial Viruses Lacking the C-Terminal Third of the Attachment (G) Protein Are Immunogenic and Attenuated In Vivo and In Vitro J. Virol., June 1, 2004; 78(11): 5773 - 5783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kuroiwa, K. Nagai, L. Okita, and H. Tsutsumi Genetic Variability and Molecular Epidemiology of Respiratory Syncytial Virus Subgroup A Strains in Japan Determined by Heteroduplex Mobility Assay J. Clin. Microbiol., May 1, 2004; 42(5): 2048 - 2053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. T. Zlateva, P. Lemey, A.-M. Vandamme, and M. Van Ranst Molecular Evolution and Circulation Patterns of Human Respiratory Syncytial Virus Subgroup A: Positively Selected Sites in the Attachment G Glycoprotein J. Virol., May 1, 2004; 78(9): 4675 - 4683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Rajala, W. M. Sullender, A. K. Prasad, L. Dar, and S. Broor Genetic Variability among Group A and B Respiratory Syncytial Virus Isolates from a Large Referral Hospital in New Delhi, India J. Clin. Microbiol., June 1, 2003; 41(6): 2311 - 2316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Venter, S. A. Madhi, C. T. Tiemessen, and B. D. Schoub Genetic diversity and molecular epidemiology of respiratory syncytial virus over four consecutive seasons in South Africa: identification of new subgroup A and B genotypes J. Gen. Virol., September 1, 2001; 82(9): 2117 - 2124. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
