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Journal of General Virology (2001), 82, 113-120.
© 2001 Society for General Microbiology

Animal: RNA Viruses

Binding of the La autoantigen to the hepatitis C virus 3' untranslated region protects the RNA from rapid degradation in vitro

Karin Spångberg1, Lisa Wiklund1 and Stefan Schwartz1

Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Husargatan 3, Box 582, 751 23 Uppsala, Sweden1

Author for correspondence: Stefan Schwartz. Fax +46 18 509 876. e-mail stefan.schwartz{at}imim.uu.se

We have analysed hepatitis C virus (HCV) RNAs in an in vitro RNA degradation assay. We found that the 3' end of positive polarity HCV RNA is sensitive to cytosolic RNases whereas the 3' end of negative polarity HCV RNA is relatively stable. Interaction of the HCV 3' untranslated region with the cellular La protein prevented premature degradation of the HCV RNA. One may speculate that HCV RNAs interact with La protein in infected cells to prevent premature degradation of the viral RNAs.




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