J Gen Virol
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Spångberg, K.
Right arrow Articles by Schwartz, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Spångberg, K.
Right arrow Articles by Schwartz, S.
Agricola
Right arrow Articles by Spångberg, K.
Right arrow Articles by Schwartz, S.
Journal of General Virology (2001), 82, 113-120.
© 2001 Society for General Microbiology

Animal: RNA Viruses

Binding of the La autoantigen to the hepatitis C virus 3' untranslated region protects the RNA from rapid degradation in vitro

Karin Spångberg1, Lisa Wiklund1 and Stefan Schwartz1

Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Husargatan 3, Box 582, 751 23 Uppsala, Sweden1

Author for correspondence: Stefan Schwartz. Fax +46 18 509 876. e-mail stefan.schwartz{at}imim.uu.se

We have analysed hepatitis C virus (HCV) RNAs in an in vitro RNA degradation assay. We found that the 3' end of positive polarity HCV RNA is sensitive to cytosolic RNases whereas the 3' end of negative polarity HCV RNA is relatively stable. Interaction of the HCV 3' untranslated region with the cellular La protein prevented premature degradation of the HCV RNA. One may speculate that HCV RNAs interact with La protein in infected cells to prevent premature degradation of the viral RNAs.




This article has been cited by other articles:


Home page
 J. Gen. Virol.Home page
S. Vashist, M. Anantpadma, H. Sharma, and S. Vrati
La protein binds the predicted loop structures in the 3' non-coding region of Japanese encephalitis virus genome: role in virus replication
J. Gen. Virol., June 1, 2009; 90(6): 1343 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
V. Bitko, A. Musiyenko, M. A. Bayfield, R. J. Maraia, and S. Barik
Cellular La Protein Shields Nonsegmented Negative-Strand RNA Viral Leader RNA from RIG-I and Enhances Virus Growth by Diverse Mechanisms
J. Virol., August 15, 2008; 82(16): 7977 - 7987.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
Z. Zhang, D. Harris, and V. N. Pandey
The FUSE Binding Protein Is a Cellular Factor Required for Efficient Replication of Hepatitis C Virus
J. Virol., June 15, 2008; 82(12): 5761 - 5773.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. You and C. M. Rice
3' RNA Elements in Hepatitis C Virus Replication: Kissing Partners and Long Poly(U)
J. Virol., January 1, 2008; 82(1): 184 - 195.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
D. Harris, Z. Zhang, B. Chaubey, and V. N. Pandey
Identification of Cellular Factors Associated with the 3'-Nontranslated Region of the Hepatitis C Virus Genome
Mol. Cell. Proteomics, June 1, 2006; 5(6): 1006 - 1018.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
R. Ivanyi-Nagy, I. Kanevsky, C. Gabus, J.-P. Lavergne, D. Ficheux, F. Penin, P. Fosse, and J.-L. Darlix
Analysis of hepatitis C virus RNA dimerization and core-RNA interactions.
Nucleic Acids Res., January 1, 2006; 34(9): 2618 - 2633.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. Pudi, S. S. Ramamurthy, and S. Das
A Peptide Derived from RNA Recognition Motif 2 of Human La Protein Binds to Hepatitis C Virus Internal Ribosome Entry Site, Prevents Ribosomal Assembly, and Inhibits Internal Initiation of Translation
J. Virol., August 1, 2005; 79(15): 9842 - 9853.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
X. Zhao, D. Oberg, M. Rush, J. Fay, H. Lambkin, and S. Schwartz
A 57-Nucleotide Upstream Early Polyadenylation Element in Human Papillomavirus Type 16 Interacts with hFip1, CstF-64, hnRNP C1/C2, and Polypyrimidine Tract Binding Protein
J. Virol., April 1, 2005; 79(7): 4270 - 4288.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Horke, K. Reumann, C. Schulze, F. Grosse, and T. Heise
The La Motif and the RNA Recognition Motifs of Human La Autoantigen Contribute Individually to RNA Recognition and Subcellular Localization
J. Biol. Chem., November 26, 2004; 279(48): 50302 - 50309.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. Ehlers, S. Horke, K. Reumann, A. Rang, F. Grosse, H. Will, and T. Heise
Functional Characterization of the Interaction between Human La and Hepatitis B Virus RNA
J. Biol. Chem., October 15, 2004; 279(42): 43437 - 43447.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Costa-Mattioli, Y. Svitkin, and N. Sonenberg
La Autoantigen Is Necessary for Optimal Function of the Poliovirus and Hepatitis C Virus Internal Ribosome Entry Site In Vivo and In Vitro
Mol. Cell. Biol., August 1, 2004; 24(15): 6861 - 6870.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Pudi, P. Srinivasan, and S. Das
La Protein Binding at the GCAC Site Near the Initiator AUG Facilitates the Ribosomal Assembly on the Hepatitis C Virus RNA to Influence Internal Ribosome Entry Site-mediated Translation
J. Biol. Chem., July 16, 2004; 279(29): 29879 - 29888.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Horke, K. Reumann, M. Schweizer, H. Will, and T. Heise
Nuclear Trafficking of La Protein Depends on a Newly Identified Nucleolar Localization Signal and the Ability to Bind RNA
J. Biol. Chem., June 18, 2004; 279(25): 26563 - 26570.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. You, D. D. Stump, A. D. Branch, and C. M. Rice
A cis-Acting Replication Element in the Sequence Encoding the NS5B RNA-Dependent RNA Polymerase Is Required for Hepatitis C Virus RNA Replication
J. Virol., February 1, 2004; 78(3): 1352 - 1366.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Pudi, S. Abhiman, N. Srinivasan, and S. Das
Hepatitis C Virus Internal Ribosome Entry Site-mediated Translation Is Stimulated by Specific Interaction of Independent Regions of Human La Autoantigen
J. Biol. Chem., March 28, 2003; 278(14): 12231 - 12240.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. M. E. Yocupicio-Monroy, F. Medina, J. Reyes-del Valle, and R. M. del Angel
Cellular Proteins from Human Monocytes Bind to Dengue 4 Virus Minus-Strand 3' Untranslated Region RNA
J. Virol., March 1, 2003; 77(5): 3067 - 3076.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. M. Smith, C. M. Walton, C. H. Wu, and G. Y. Wu
Secondary Structure and Hybridization Accessibility of Hepatitis C Virus 3'-Terminal Sequences
J. Virol., October 1, 2002; 76(19): 9563 - 9574.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Horke, K. Reumann, A. Rang, and T. Heise
Molecular Characterization of the Human La Protein{middle dot}Hepatitis B Virus RNA.B Interaction in Vitro
J. Biol. Chem., September 13, 2002; 277(38): 34949 - 34958.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
P. Friebe and R. Bartenschlager
Genetic Analysis of Sequences in the 3' Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication
J. Virol., June 1, 2002; 76(11): 5326 - 5338.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
J.S. KIEFT, A. GRECH, P. ADAMS, and J.A. DOUDNA
Mechanisms of Internal Ribosome Entry in Translation Initiation
Cold Spring Harb Symp Quant Biol, January 1, 2001; 66(0): 277 - 284.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2001 by the Society for General Microbiology.