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Journal of General Virology (2001), 82, 2319-2326.
© 2001 Society for General Microbiology

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Distribution of the prion protein in sheep terminally affected with BSE following experimental oral transmission

J. D. Foster1, D. W. Parnham1, N. Hunter1 and M. Bruce1

Institute for Animal Health, Neuropathogenesis Unit, Edinburgh EH9 3JF, UK1

Author for correspondence: James Foster. Fax +44 131 668 3872. e-mail Jim.Foster{at}BBSRC.AC.UK

This study has examined the distribution of PrPSc in sheep by immunocytochemistry of tissues recovered from terminally affected animals following their experimental infection by the oral route with BSE. Despite a wide range of incubation period lengths, affected sheep showed a similar distribution of high levels of PrPSc throughout the central nervous system. PrPSc was also found in the lymphoid system, including parts of the digestive tract, and some components of the peripheral nervous system. These abundant PrPSc deposits in sheep in regions outside the central nervous system are in direct contrast with cattle infected with BSE, which show barely detectable levels of PrPSc in peripheral tissues. A number of genetically susceptible, challenged animals appear to have survived.




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