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Animal: RNA Viruses |
Unité des Rétrovirus Endogènes et Eléments Rétroïdes des Eukaryotes Supérieurs, UMR 1573 CNRS, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France1
CEPH, 27 rue Juliette Dodu, 75010 Paris, France2
Author for correspondence: Thierry Heidmann. Fax +33 1 42 11 53 42. e-mail heidmann{at}igr.fr
We have demonstrated previously that the envelope proteins of a murine retrovirus (Moloney murine leukaemia virus) and a simian retrovirus (Mason–Pfizer monkey virus) have immunosuppressive properties in vivo. This property was manifested by the ability of the proteins, when expressed by tumour cells normally rejected by engrafted mice, to allow the envelope-expressing cells to escape immune rejection and to proliferate. Here, it is shown that this property is not restricted to the envelope of infectious retroviruses, but is also shared by the envelope protein encoded by an endogenous retrovirus of humans belonging to the HERV-H family. These results emphasize the close relationship between endogenous and infectious retroviruses and might be important in relation to the process of tumour progression in humans.
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N. de Parseval, V. Lazar, J.-F. Casella, L. Benit, and T. Heidmann Survey of Human Genes of Retroviral Origin: Identification and Transcriptome of the Genes with Coding Capacity for Complete Envelope Proteins J. Virol., October 1, 2003; 77(19): 10414 - 10422. [Abstract] [Full Text] [PDF]
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L. Benit, P. Dessen, and T. Heidmann Identification, Phylogeny, and Evolution of Retroviral Elements Based on Their Envelope Genes J. Virol., December 1, 2001; 75(23): 11709 - 11719. [Abstract] [Full Text]
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