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Interaction of lyssaviruses with the low-affinity nerve-growth factor receptor p75^NTR

Laboratoire de Génétique des Virus, Bat 14B, Centre National de la Recherche Scientifique, 91198, Gif sur Yvette Cedex, France¹
Laboratoire des Lyssavirus, Institut Pasteur, 28, rue du Dr. Roux, 75724 Paris Cedex 15, France²

Author for correspondence: Christine Tuffereau. Fax +33 1 69 82 43 08. email ctuffer{at}gv.cnrs-gif.fr

The low-affinity nerve-growth factor receptor p75^NTR interacts in vitro with the rabies virus (RV) glycoprotein and serves as a receptor for RV. The Lyssavirus genus comprises seven genotypes (GTs) of rabies and rabies-related viruses. The ability of p75^NTR to interact with the glycoprotein of representative lyssaviruses from each GT was investigated. This investigation was based on a specific binding assay between BSR cells infected with a lyssavirus and Spodoptera frugiperda (Sf21) cells expressing p75^NTR on the cell surface. A specific interaction was observed with the glycoprotein of GT 1 RV (challenge virus standard or Pasteur virus strains) as well as wild-type RV and the glycoprotein of GT 6 European bat lyssavirus type 2. In contrast, no interaction was detected with the glycoprotein of lyssaviruses of GTs 2–5 and 7. Therefore, p75^NTR is only a receptor for some lyssavirus glycoproteins, indicating that the other GTs must use an alternative specific receptor.

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