J Gen Virol Try IJSEM Online
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chouljenko, V. N.
Right arrow Articles by Gorbalenya, A. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chouljenko, V. N.
Right arrow Articles by Gorbalenya, A. E.
Agricola
Right arrow Articles by Chouljenko, V. N.
Right arrow Articles by Gorbalenya, A. E.
Journal of General Virology (2001), 82, 2927-2933.
© 2001 Society for General Microbiology

Animal: RNA Viruses

Comparison of genomic and predicted amino acid sequences of respiratory and enteric bovine coronaviruses isolated from the same animal with fatal shipping pneumonia

Vladimir N. Chouljenko1, X. Q. Lin1, J. Storz1, Konstantin G. Kousoulas1 and Alexander E. Gorbalenya2

Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA1
Advanced Biomedical Computing Center, Science Application International Corporation, National Cancer Institute, Frederick, MD 21702-1201, USA2

Author for correspondence: Konstantin Kousoulas. Fax +1 225 578 9701. e-mail vtgusk{at}lsu.edu

The complete genome sequences are reported here of two field isolates of bovine coronavirus (BCoV), which were isolated from respiratory and intestinal samples of the same animal experiencing fatal pneumonia during a bovine shipping fever epizootic. Both genomes contained 31028 nucleotides and included 13 open reading frames (ORFs) flanked by 5'- and 3'-untranslated regions (UTRs). ORF1a and ORF1b encode replicative polyproteins pp1a and pp1ab, respectively, that contain all of the putative functional domains documented previously for the closest relative, mouse hepatitis virus. The genomes of the BCoV isolates differed in 107 positions, scattered throughout the genome except the 5'-UTR. Differences in 25 positions were non-synonymous and were located in all proteins except pp1b. Six replicase mutations were identified within or immediately downstream of the predicted largest pp1a-derived protein, p195/p210. Single amino acid changes within p195/p210 as well as within the S glycoprotein might contribute to the different phenotypes of the BCoV isolates.




This article has been cited by other articles:


Home page
 J. Virol.Home page
K. P. Alekseev, A. N. Vlasova, K. Jung, M. Hasoksuz, X. Zhang, R. Halpin, S. Wang, E. Ghedin, D. Spiro, and L. J. Saif
Bovine-Like Coronaviruses Isolated from Four Species of Captive Wild Ruminants Are Homologous to Bovine Coronaviruses, Based on Complete Genomic Sequences
J. Virol., December 15, 2008; 82(24): 12422 - 12431.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. Ziebuhr, B. Schelle, N. Karl, E. Minskaia, S. Bayer, S. G. Siddell, A. E. Gorbalenya, and V. Thiel
Human Coronavirus 229E Papain-Like Proteases Have Overlapping Specificities but Distinct Functions in Viral Replication
J. Virol., April 15, 2007; 81(8): 3922 - 3932.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
L. Liu, S. Hagglund, M. Hakhverdyan, S. Alenius, L. E. Larsen, and S. Belak
Molecular epidemiology of bovine coronavirus on the basis of comparative analyses of the s gene.
J. Clin. Microbiol., March 1, 2006; 44(3): 957 - 960.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
L. Vijgen, E. Keyaerts, E. Moes, I. Thoelen, E. Wollants, P. Lemey, A.-M. Vandamme, and M. Van Ranst
Complete Genomic Sequence of Human Coronavirus OC43: Molecular Clock Analysis Suggests a Relatively Recent Zoonotic Coronavirus Transmission Event
J. Virol., February 1, 2005; 79(3): 1595 - 1604.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. R. St-Jean, H. Jacomy, M. Desforges, A. Vabret, F. Freymuth, and P. J. Talbot
Human Respiratory Coronavirus OC43: Genetic Stability and Neuroinvasion
J. Virol., August 15, 2004; 78(16): 8824 - 8834.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. E. Gorbalenya, E. J. Snijder, and W. J. M. Spaan
Severe Acute Respiratory Syndrome Coronavirus Phylogeny: toward Consensus
J. Virol., August 1, 2004; 78(15): 7863 - 7866.
[Full Text] [PDF]

Home page
 J. Virol.Home page
S. Raman, P. Bouma, G. D. Williams, and D. A. Brian
Stem-Loop III in the 5' Untranslated Region Is a cis-Acting Element in Bovine Coronavirus Defective Interfering RNA Replication
J. Virol., June 15, 2003; 77(12): 6720 - 6730.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
X.-Q. Lin, K. L. O'Reilly, and J. Storz
Antibody Responses of Cattle with Respiratory Coronavirus Infections during Pathogenesis of Shipping Fever Pneumonia Are Lower with Antigens of Enteric Strains than with Those of a Respiratory Strain
Clin. Vaccine Immunol., September 1, 2002; 9(5): 1010 - 1013.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
A. Hegyi, A. Friebe, A. E. Gorbalenya, and J. Ziebuhr
Mutational analysis of the active centre of coronavirus 3C-like proteases
J. Gen. Virol., March 1, 2002; 83(3): 581 - 593.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2001 by the Society for General Microbiology.