J Gen Virol Faster Access
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kerr, J. R.
Right arrow Articles by Tyrrell, D. A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kerr, J. R.
Right arrow Articles by Tyrrell, D. A. J.
Agricola
Right arrow Articles by Kerr, J. R.
Right arrow Articles by Tyrrell, D. A. J.
Journal of General Virology (2001), 82, 3011-3019.
© 2001 Society for General Microbiology

Animal: DNA Viruses

Circulating tumour necrosis factor-{alpha} and interferon-{gamma} are detectable during acute and convalescent parvovirus B19 infection and are associated with prolonged and chronic fatigue

Jonathan R. Kerr1, Faraj Barah2, Derek L. Mattey3, Ian Laing4, Stephen J. Hopkins5, Ian V. Hutchinson6 and David A. J. Tyrrell7

Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College School of Medicine, Sydney Street, London SW3 6NP, UK1
Department of Virology2, North Western Injury Research Centre5 and School of Biological Sciences6, University of Manchester, Manchester, UK
Staffordshire Rheumatology Centre, Stoke-on-Trent, UK3
Department of Biochemistry, Manchester Royal Infirmary, Manchester, UK4
Formerly of the MRC Common Cold Unit, Salisbury, Wiltshire, UK(now closed)7

Author for correspondence: Jonathan Kerr. Fax +44 207 351 8443. e-mail j.kerr{at}ic.ac.uk

To investigate whether cytokine responses may have a bearing on the symptoms and outcome of parvovirus B19 infection, circulating cytokines were measured during acute infection (n=51), follow-up of acute infection (n=39) and in normal healthy controls (n=50). At acute B19 virus infection (serum anti-B19 IgM-positive), patients ranged in age from 4 to 54 years, with a mean age of 28·2 years. The male:female ratio was 1:4·1 and symptoms were rash (n=15), arthralgia (n=31), fatigue (n=8), lymphadenopathy (n=4), foetal hydrops (n=3), transient aplastic crisis (n=2), neutropenia (n=2), myelodysplasia (n=1), thrombocytopenia (n=1) and pancytopenia (n=1). Of these patients, 39 were contacted after a follow-up period of 2–37 months (mean of 22·5 months). In comparison with normal controls, detectable IL-6 was associated with acute B19 virus infection (26%; P=0·0003), but not with follow-up (6%; P=0·16). Detection of interferon (IFN)-{gamma} was associated with acute B19 virus infection (67%; P<0·0001) and follow-up (67%; P<0·0001). Detection of tumour necrosis factor (TNF)-{alpha} was associated with acute B19 virus infection (49%; P<0·0001) and follow-up (56%; P<0·0001). IL-1{beta} was detected in acute infection (20%), but not at follow-up. At acute B19 virus infection, detection of serum/plasma IL-6 was associated with rheumatoid factor (P=0·038) and IFN-{gamma} (>=7 pg/ml) was associated with fatigue in those patients of >=15 years of age (P=0·022). At follow-up, fatigue was associated with IFN-{gamma} (>=7 pg/ml) and/or TNF-{alpha} (>=40 pg/ml) (P=0·0275). Prolonged upregulation of serum IFN-{gamma} and TNF-{alpha} appears to represent a consistent host response to symptomatic B19 virus infection.




This article has been cited by other articles:


Home page
 BloodHome page
Y. Munakata, T. Saito-Ito, K. Kumura-Ishii, J. Huang, T. Kodera, T. Ishii, Y. Hirabayashi, Y. Koyanagi, and T. Sasaki
Ku80 autoantigen as a cellular coreceptor for human parvovirus B19 infection
Blood, November 15, 2005; 106(10): 3449 - 3456.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
A. Shafqat, L. H. Einhorn, N. Hanna, G. W. Sledge, A. Hanna, B. E. Juliar, P. Monahan, and S. Bhatia
Screening studies for fatigue and laboratory correlates in cancer patients undergoing treatment{dagger}
Ann. Onc., September 1, 2005; 16(9): 1545 - 1550.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
K. Helbig, R. Harris, J. Ayres, H. Dunckley, A. Lloyd, J. Robson, and B.P. Marmion
Immune response genes in the post-Q-fever fatigue syndrome, Q fever endocarditis and uncomplicated acute primary Q fever
QJM, August 1, 2005; 98(8): 565 - 574.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
N Kaushik, D Fear, S C M Richards, C R McDermott, E F Nuwaysir, P Kellam, T J Harrison, R J Wilkinson, D A J Tyrrell, S T Holgate, et al.
Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome
J. Clin. Pathol., August 1, 2005; 58(8): 826 - 832.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
J Smith, E L Fritz, J R Kerr, A J Cleare, S Wessely, and D L Mattey
Association of chronic fatigue syndrome with human leucocyte antigen class II alleles
J. Clin. Pathol., August 1, 2005; 58(8): 860 - 863.
[Abstract] [Full Text] [PDF]

Home page
 J Med MicrobiolHome page
A. Corcoran and S. Doyle
Advances in the biology, diagnosis and host-pathogen interactions of parvovirus B19
J. Med. Microbiol., June 1, 2004; 53(6): 459 - 475.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
P. Flachenecker, I. Bihler, F Weber, M Gottschalk, K. V Toyka, and P. Rieckmann
Cytokine mRNA expression in patients with multiple sclerosis and fatigue
Multiple Sclerosis, April 1, 2004; 10(2): 165 - 169.
[Abstract] [PDF]

Home page
 PediatricsHome page
P. C. Ng, C. W.K. Lam, A. M. Li, C. K. Wong, F. W.T. Cheng, T. F. Leung, E. K.L. Hon, I. H.S. Chan, C. K. Li, K. S.C. Fung, et al.
Inflammatory Cytokine Profile in Children With Severe Acute Respiratory Syndrome
Pediatrics, January 1, 2004; 113(1): e7 - 14.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
J R Kerr, F Barah, V S Cunniffe, J Smith, P J Vallely, A M Will, R F Wynn, R F Stevens, G M Taylor, G M Cleator, et al.
Association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia
J. Clin. Pathol., November 1, 2003; 56(11): 873 - 875.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
R J M Lane, B A Soteriou, H Zhang, and L C Archard
Enterovirus related metabolic myopathy: a postviral fatigue syndrome
J. Neurol. Neurosurg. Psychiatry, October 1, 2003; 74(10): 1382 - 1386.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
J R Kerr, M McCoy, B Burke, D L Mattey, V Pravica, and I V Hutchinson
Cytokine gene polymorphisms associated with symptomatic parvovirus B19 infection
J. Clin. Pathol., October 1, 2003; 56(10): 725 - 727.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J R Kerr, F Barah, M L Chiswick, G V McDonnell, J Smith, M D Chapman, J B Bingham, P Kelleher, and M N Sheppard
Evidence for the role of demyelination, HLA-DR alleles, and cytokines in the pathogenesis of parvovirus B19 meningoencephalitis and its sequelae
J. Neurol. Neurosurg. Psychiatry, December 1, 2002; 73(6): 739 - 746.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
J. R. Kerr and W. M. H. Behan
High mutation rate in the NS1 gene of parvovirus B19 DNA amplified from skeletal muscle of a case of mixed connective tissue disease
Rheumatology, July 1, 2002; 41(7): 833 - 834.
[Full Text] [PDF]

Home page
 J. Virol.Home page
Y. Fu, K. K. Ishii, Y. Munakata, T. Saitoh, M. Kaku, and T. Sasaki
Regulation of Tumor Necrosis Factor Alpha Promoter by Human Parvovirus B19 NS1 through Activation of AP-1 and AP-2
J. Virol., May 3, 2002; 76(11): 5395 - 5403.
[Abstract] [Full Text] [PDF]

Home page
 Biol Res NursHome page
E. J. Corwin, L. C. Klein, and K. Rickelman
Predictors of Fatigue in Healthy Young Adults: Moderating Effects of Cigarette Smoking and Gender
Biol Res Nurs, April 1, 2002; 3(4): 222 - 233.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2001 by the Society for General Microbiology.