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Animal: DNA Viruses |
Department of Veterinary and Biomedical Sciences, Center for Biotechnology, University of Nebraska, Lincoln, Fair Street at East Campus Loop, Lincoln, NE 68583-0905, USA1
Author for correspondence: Clinton Jones. Fax +1 402 472 9690. e-mail cjones{at}unlnotes.unl.edu
The bICP0 protein encoded by bovine herpesvirus 1 (BHV-1) is believed to activate transcription and consequently productive infection. Expression of full-length bICP0 protein is toxic in transiently transfected mouse neuroblastoma cells (neuro-2A) in the absence of other viral genes. However, bICP0 does not appear to directly induce apoptosis. Although bICP0 is believed to be functionally similar to the herpes simplex virus type 1-encoded ICP0, the only protein domain that is well conserved is a C3HC4 zinc ring finger located near the N terminus of both proteins. Site-specific mutagenesis of the zinc ring finger of bICP0 demonstrated that it was important for inducing aggregated chromatin structures in transfected cells and toxicity. The zinc ring finger was also required for stimulating productive infection in bovine cells and for trans-activating the thymidine kinase (TK) promoter of herpes simplex virus type 1. Deletion of amino acids spanning 356–677 of bICP0 altered subcellular localization of bICP0 and prevented trans-activation of the TK promoter. However, this deletion did not prevent trans-activation of the viral genome. Taken together, these studies indicated that bICP0 has several functional domains, including the zinc ring finger, which stimulate productive infection and influence cell survival.
This article has been cited by other articles:
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  K. Saira, Y. Zhou, and C. Jones The Infected Cell Protein 0 Encoded by Bovine Herpesvirus 1 (bICP0) Induces Degradation of Interferon Response Factor 3 and, Consequently, Inhibits Beta Interferon Promoter Activity J. Virol., April 1, 2007; 81(7): 3077 - 3086. [Abstract] [Full Text] [PDF]
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F. Meyer, S. Perez, V. Geiser, M. Sintek, M. Inman, and C. Jones A Protein Encoded by the Bovine Herpesvirus 1 Latency-Related Gene Interacts with Specific Cellular Regulatory Proteins, Including CCAAT Enhancer Binding Protein Alpha J. Virol., January 1, 2007; 81(1): 59 - 67. [Abstract] [Full Text] [PDF]
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 Y. Zhang, Y. Jiang, V. Geiser, J. Zhou, and C. Jones Bovine herpesvirus 1 immediate-early protein (bICP0) interacts with the histone acetyltransferase p300, which stimulates productive infection and gC promoter activity J. Gen. Virol., July 1, 2006; 87(7): 1843 - 1851. [Abstract] [Full Text] [PDF]
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G. Henderson, Y. Zhang, and C. Jones The bovine herpesvirus 1 gene encoding infected cell protein 0 (bICP0) can inhibit interferon-dependent transcription in the absence of other viral genes J. Gen. Virol., October 1, 2005; 86(10): 2697 - 2702. [Abstract] [Full Text] [PDF]
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V. Geiser, Y. Zhang, and C. Jones Analysis of a bovine herpesvirus 1 recombinant virus that does not express the bICP0 protein J. Gen. Virol., July 1, 2005; 86(7): 1987 - 1996. [Abstract] [Full Text] [PDF]
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W. Peng, G. Henderson, M. Inman, L. BenMohamed, G.-C. Perng, S. L. Wechsler, and C. Jones The Locus Encompassing the Latency-Associated Transcript of Herpes Simplex Virus Type 1 Interferes with and Delays Interferon Expression in Productively Infected Neuroblastoma Cells and Trigeminal Ganglia of Acutely Infected Mice J. Virol., May 15, 2005; 79(10): 6162 - 6171. [Abstract] [Full Text] [PDF]
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Y. Zhang, J. Zhou, and C. Jones Identification of functional domains within the bICP0 protein encoded by bovine herpesvirus 1 J. Gen. Virol., April 1, 2005; 86(4): 879 - 886. [Abstract] [Full Text] [PDF]
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G. Henderson, Y. Zhang, M. Inman, D. Jones, and C. Jones Infected cell protein 0 encoded by bovine herpesvirus 1 can activate caspase 3 when overexpressed in transfected cells J. Gen. Virol., December 1, 2004; 85(12): 3511 - 3516. [Abstract] [Full Text] [PDF]
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M. Inman, J. Zhou, H. Webb, and C. Jones Identification of a Novel Bovine Herpesvirus 1 Transcript Containing a Small Open Reading Frame That Is Expressed in Trigeminal Ganglia of Latently Infected Cattle J. Virol., May 15, 2004; 78(10): 5438 - 5447. [Abstract] [Full Text] [PDF]
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G. Delhon, M. P. Moraes, Z. Lu, C. L. Afonso, E. F. Flores, R. Weiblen, G. F. Kutish, and D. L. Rock Genome of Bovine Herpesvirus 5 J. Virol., October 1, 2003; 77(19): 10339 - 10347. [Abstract] [Full Text] [PDF]
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V. Geiser and C. Jones Stimulation of bovine herpesvirus-1 productive infection by the adenovirus E1A gene and a cell cycle regulatory gene, E2F-4 J. Gen. Virol., April 1, 2003; 84(4): 929 - 938. [Abstract] [Full Text] [PDF]
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V. Geiser, M. Inman, Y. Zhang, and C. Jones The latency-related gene of bovine herpesvirus-1 can inhibit the ability of bICP0 to activate productive infection J. Gen. Virol., December 1, 2002; 83(12): 2965 - 2971. [Abstract] [Full Text] [PDF]
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G. A. Delhon, M. J. Gonzalez, and P. R. Murcia Susceptibility of sensory neurons to apoptosis following infection by bovine herpesvirus type 1 J. Gen. Virol., September 1, 2002; 83(9): 2257 - 2267. [Abstract] [Full Text] [PDF]
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Y. Zhang and C. Jones The Bovine Herpesvirus 1 Immediate-Early Protein (bICP0) Associates with Histone Deacetylase 1 To Activate Transcription J. Virol., October 15, 2001; 75(20): 9571 - 9578. [Abstract] [Full Text] [PDF]
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M. Inman, L. Lovato, A. Doster, and C. Jones A Mutation in the Latency-Related Gene of Bovine Herpesvirus 1 Leads to Impaired Ocular Shedding in Acutely Infected Calves J. Virol., September 15, 2001; 75(18): 8507 - 8515. [Abstract] [Full Text] [PDF]
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