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Animal: DNA Viruses |
Laboratoire de virologie humaine, U412 INSERM, ENS-Lyon, 46 allée d’Italie, 69364 Lyon cedex 07, France1
Author for correspondence: Henri Gruffat. Fax +33 4 72 72 87 77. e-mail hgruffat{at}cri.ens-lyon.fr
The K8 protein of Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8 is a member of the bZIP family of transcription factors, which has homology with the Epstein–Barr virus transcription and replication factor, EB1. In this report, we have analysed the subcellular localization of the K8 protein and characterized a 12 amino acid sequence rich in basic residues which is responsible for targeting the protein to the cell nucleus. Furthermore, we show that a K8 mutant lacking the nuclear localization sequence can be directed to the nucleus by co-expression with an intact K8 protein, suggesting that K8 homodimerizes in the cytoplasm of the cell in vivo.
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G. Sander, A. Konrad, M. Thurau, E. Wies, R. Leubert, E. Kremmer, H. Dinkel, T. Schulz, F. Neipel, and M. Sturzl Intracellular Localization Map of Human Herpesvirus 8 Proteins J. Virol., February 15, 2008; 82(4): 1908 - 1922. [Abstract] [Full Text] [PDF]
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S. Lefort, A. Soucy-Faulkner, N. Grandvaux, and L. Flamand Binding of Kaposi's Sarcoma-Associated Herpesvirus K-bZIP to Interferon-Responsive Factor 3 Elements Modulates Antiviral Gene Expression J. Virol., October 15, 2007; 81(20): 10950 - 10960. [Abstract] [Full Text] [PDF]
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S. Al Mehairi, E. Cerasoli, and A. J. Sinclair Investigation of the Multimerization Region of the Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Protein K-bZIP: the Proposed Leucine Zipper Region Encodes a Multimerization Domain with an Unusual Structure J. Virol., June 15, 2005; 79(12): 7905 - 7910. [Abstract] [Full Text] [PDF]
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 A. J. Sinclair bZIP proteins of human gammaherpesviruses J. Gen. Virol., August 1, 2003; 84(8): 1941 - 1949. [Abstract] [Full Text] [PDF]
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S. Hwang, D. Lee, Y. Gwack, H. Min, and J. Choe Kaposi's sarcoma-associated herpesvirus K8 protein interacts with hSNF5 J. Gen. Virol., March 1, 2003; 84(3): 665 - 676. [Abstract] [Full Text] [PDF]
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 S. Tang and Z.-M. Zheng Kaposi's Sarcoma-associated Herpesvirus K8 Exon 3 Contains Three 5'-Splice Sites and Harbors a K8.1 Transcription Start Site J. Biol. Chem., April 19, 2002; 277(17): 14547 - 14556. [Abstract] [Full Text] [PDF]
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S. Hwang, Y. Gwack, H. Byun, C. Lim, and J. Choe The Kaposi's Sarcoma-Associated Herpesvirus K8 Protein Interacts with CREB-Binding Protein (CBP) and Represses CBP-Mediated Transcription J. Virol., October 1, 2001; 75(19): 9509 - 9516. [Abstract] [Full Text] [PDF]
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