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Re-analysis of human immunodeficiency virus type 1 isolates from Cyprus and Greece, initially designated ‘subtype I’, reveals a unique complex A/G/H/K/? mosaic pattern

National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, M. Asias 75, Athens 115 27, Greece¹
Rega Institute for Medical Research and University Hospitals, Katholieke Universiteit Leuven, Belgium²
Aaron Diamond AIDS Research Center, The Rockefeller University, New York 10016, USA³

Author for correspondence: Angelos Hatzakis. Fax +30 1 7719725. e-mail ahatzak{at}cc.uoa.gr

Human immunodeficiency virus type 1 (HIV-1) has been classified into three main groups and 11 distinct subtypes. Moreover, several circulating recombinant forms (CRFs) of HIV-1 have been recently documented to have spread widely causing extensive HIV-1 epidemics. A subtype, initially designated I (CRF04_cpx), was documented in Cyprus and Greece and was found to comprise regions of sequence derived from subtypes A and G as well as regions of unclassified sequence. Re-analysis of the three full-length CRF04_cpx sequences that were available revealed a mosaic genomic organization of unique complexity comprising regions of sequence from at least five distinct subtypes, A, G, H, K and unclassified regions. These strains account for approximately 2% of the total HIV-1-infected population in Greece, thus providing evidence of the great capability of HIV-1 to recombine and produce highly divergent strains which can be spread successfully through different infection routes.

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				D. Paraskevis, E. Magiorkinis, G. Magiorkinis, C. Anastassopoulou, M. Lazanas, G. Chrysos, A. M. Vandamme, and A. Hatzakis Molecular characterization of a complex, recombinant human immunodeficiency virus type 1 (HIV-1) isolate (A/G/J/K/?): evidence to support the existence of a novel HIV-1 subtype J. Gen. Virol., October 1, 2001; 82(10): 2509 - 2514. [Abstract] [Full Text] [PDF]