| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Animal: RNA Viruses |
Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK1
Author for correspondence: Alan Samuel. Fax +44 1483 232448. e-mail alan.samuel{at}bbsrc.ac.uk
Serotype O is the most prevalent of the seven serotypes of foot-and-mouth disease (FMD) virus and occurs in many parts of the world. The UPGMA method was used to construct a phylogenetic tree based on nucleotide sequences at the 3' end of the VP1 gene from 105 FMD type O viruses obtained from samples submitted to the OIE/FAO World Reference Laboratory for FMD. This analysis identified eight major genotypes when a value of 15% nucleotide difference was used as a cut-off. The validity of these groupings was tested on the complete VP1 gene sequences of 23 of these viruses by bootstrap resampling and construction of a neighbour-joining tree. These eight genetic lineages fell within geographical boundaries and we have used the term topotype to describe them. Using a large sequence database, the distribution of viruses belonging to each of the eight topotypes has been determined. These phylogenetically based epidemiological studies have also been used to identify viruses that have transgressed their normal ecological niches. Despite the high rate of mutation during replication of the FMD virus genome, the topotypes appear to represent evolutionary cul-de-sacs.
This article has been cited by other articles:
|
|
 |
|
  A. M. Perez, G. Konig, E. Spath, and M. C. Thurmond Variation in the VP1 gene of Foot-and-mouth disease virus serotype A associated with epidemiological characteristics of outbreaks in the 2001 epizootic in Argentina J Vet Diagn Invest, July 1, 2008; 20(4): 433 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Carrillo, Z. Lu, M. V. Borca, A. Vagnozzi, G. F. Kutish, and D. L. Rock Genetic and Phenotypic Variation of Foot-and-Mouth Disease Virus during Serial Passages in a Natural Host J. Virol., October 15, 2007; 81(20): 11341 - 11351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Diaz-San Segundo, F. J. Salguero, A. de Avila, M. M. Fernandez de Marco, M. A. Sanchez-Martin, and N. Sevilla Selective Lymphocyte Depletion during the Early Stage of the Immune Response to Foot-and-Mouth Disease Virus Infection in Swine J. Virol., March 1, 2006; 80(5): 2369 - 2379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. d. C. Bronsvoort, A. D. Radford, V. N. Tanya, C. Nfon, R. P. Kitching, and K. L. Morgan Molecular Epidemiology of Foot-and-Mouth Disease Viruses in the Adamawa Province of Cameroon J. Clin. Microbiol., May 1, 2004; 42(5): 2186 - 2196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. T. Haydon, A. D. S. Bastos, and P. Awadalla Low linkage disequilibrium indicative of recombination in foot-and-mouth disease virus gene sequence alignments J. Gen. Virol., May 1, 2004; 85(5): 1095 - 1100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Mason, J. M. Pacheco, Q.-Z. Zhao, and N. J. Knowles Comparisons of the complete genomes of Asian, African and European isolates of a recent foot-and-mouth disease virus type O pandemic strain (PanAsia) J. Gen. Virol., June 1, 2003; 84(6): 1583 - 1593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. S. Bastos, D. T. Haydon, O. Sangare, C. I. Boshoff, J. L. Edrich, and G. R. Thomson The implications of virus diversity within the SAT 2 serotype for control of foot-and-mouth disease in sub-Saharan Africa J. Gen. Virol., June 1, 2003; 84(6): 1595 - 1606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Zhao, J. M. Pacheco, and P. W. Mason Evaluation of Genetically Engineered Derivatives of a Chinese Strain of Foot-and-Mouth Disease Virus Reveals a Novel Cell-Binding Site Which Functions in Cell Culture and in Animals J. Virol., March 1, 2003; 77(5): 3269 - 3280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tosh, D. Hemadri, and A. Sanyal Evidence of recombination in the capsid-coding region of type A foot-and-mouth disease virus J. Gen. Virol., October 1, 2002; 83(10): 2455 - 2460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J. Hughes, V. Mioulet, D. T. Haydon, R. P. Kitching, A. I. Donaldson, and M. E. J. Woolhouse Serial passage of foot-and-mouth disease virus in sheep reveals declining levels of viraemia over time J. Gen. Virol., August 1, 2002; 83(8): 1907 - 1914. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
