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Journal of General Virology (2001), 82, 1175-1180.
© 2001 Society for General Microbiology

Animal: DNA Viruses

Major histocompatibility complex class I molecules are down-regulated at the cell surface by the K5 protein encoded by Kaposi’s sarcoma-associated herpesvirus/human herpesvirus-8

Muzammel Haque1, Keiji Ueda1, Kazushi Nakano1, Yuko Hirata1, Carlo Parravicini2, Mario Corbellino3 and Koichi Yamanishi1

Department of Microbiology, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan1
Department of Pathology2 and Institute of Infectious Diseases3, University of Milan, ‘L. Sacco’ Hospital, Milan, Italy

Author for correspondence: Koichi Yamanishi. Fax +81 6 6879 3329. e-mail yamanisi{at}micro.med.osaka-u.ac.jp

The expression of major histocompatibility complex class I (MHC-I) molecules at the cell surface was down-regulated in BC-3 cells infected with Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8 at early times after treatment with 12-O-tetradecanoylphorbol acetate (TPA), and in HeLa cells transfected with the K5 gene of KSHV. However, an immunoprecipitation study on these cells with anti-MHC-I monoclonal antibody revealed that there was no significant reduction in the synthesis of MHC-I molecules. A pulse–chase analysis followed by endoglycosidase H digestion also demonstrated the stability and transport of MHC-I molecules from the endoplasmic reticulum to at least the medial-Golgi. K5 antigen was clearly detected by immunohistological examination of samples from Kaposi’s sarcoma, primary effusion lymphoma and Castleman’s disease. These results suggest that the down-regulation of MHC-I molecules by K5 gene expression during reactivation may be important for evading immunological surveillance in the host.




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