HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Blaise, S. Articles by Heidmann, T. Search for Related Content PubMed PubMed Citation Articles by Blaise, S. Articles by Heidmann, T. Agricola Articles by Blaise, S. Articles by Heidmann, T.

The envelope of Mason–Pfizer monkey virus has immunosuppressive properties

Unité des Rétrovirus Endogènes et Eléments Rétroïdes des Eukaryotes Supérieurs, UMR 1573 CNRS, Institut Gustave Roussy, 94805 Villejuif, France¹

Author for correspondence: Thierry Heidmann. Fax +33 1 42 11 53 42. e-mail heidmann{at}igr.fr

We have demonstrated previously that the envelope protein of a murine retrovirus, Moloney murine leukaemia virus, has immunosuppressive properties in vivo. This property was manifested by the ability of the protein, when expressed by tumour cells normally rejected by engrafted mice, to allow the env-expressing cells to escape immune rejection and to proliferate. Here, it is shown that this property is not restricted to the envelope of a murine retrovirus, but is also shared by the envelope encoded by a primate retrovirus, Mason–Pfizer monkey virus.

This article has been cited by other articles:

				J. Sugimoto and D. J. Schust Review: Human Endogenous Retroviruses and the Placenta Reproductive Sciences, November 1, 2009; 16(11): 1023 - 1033. [Abstract] [PDF]

				A. Dupressoir, C. Vernochet, O. Bawa, F. Harper, G. Pierron, P. Opolon, and T. Heidmann From the Cover: Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene PNAS, July 21, 2009; 106(29): 12127 - 12132. [Abstract] [Full Text] [PDF]

				M. Mangeney, M. Renard, G. Schlecht-Louf, I. Bouallaga, O. Heidmann, C. Letzelter, A. Richaud, B. Ducos, and T. Heidmann Placental syncytins: Genetic disjunction between the fusogenic and immunosuppressive activity of retroviral envelope proteins PNAS, December 18, 2007; 104(51): 20534 - 20539. [Abstract] [Full Text] [PDF]

				K. Buscher, U. Trefzer, M. Hofmann, W. Sterry, R. Kurth, and J. Denner Expression of Human Endogenous Retrovirus K in Melanomas and Melanoma Cell Lines Cancer Res., May 15, 2005; 65(10): 4172 - 4180. [Abstract] [Full Text] [PDF]

				N. de Parseval, V. Lazar, J.-F. Casella, L. Benit, and T. Heidmann Survey of Human Genes of Retroviral Origin: Identification and Transcriptome of the Genes with Coding Capacity for Complete Envelope Proteins J. Virol., October 1, 2003; 77(19): 10414 - 10422. [Abstract] [Full Text] [PDF]

				A. Ortin, C. Cousens, E. Minguijon, Z. Pascual, M. P. d. Villarreal, J. M. Sharp, and M. D. l. Heras Characterization of enzootic nasal tumour virus of goats: complete sequence and tissue distribution J. Gen. Virol., August 1, 2003; 84(8): 2245 - 2252. [Abstract] [Full Text] [PDF]

				L. Benit, P. Dessen, and T. Heidmann Identification, Phylogeny, and Evolution of Retroviral Elements Based on Their Envelope Genes J. Virol., December 1, 2001; 75(23): 11709 - 11719. [Abstract] [Full Text]

				M. Mangeney, N. de Parseval, G. Thomas, and T. Heidmann The full-length envelope of an HERV-H human endogenous retrovirus has immunosuppressive properties J. Gen. Virol., October 1, 2001; 82(10): 2515 - 2518. [Abstract] [Full Text] [PDF]