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Phylogenetic reconstruction of intrapatient evolution of human immunodeficiency virus type 1: predominance of drift and purifying selection

Abteilung Virologie, Universität des Saarlandes, Institut für Medizinische Mikrobiologie und Hygiene, Klinikum Homburg, Haus 47, D-66421 Homburg, Germany¹
Unité de Rétrovirologie Moléculaire, Institut Pasteur, F-75724 Paris cedex 15, France²

Author for correspondence: Andreas Meyerhans. Fax +49 6841 16 3980. e-mail Andreas.Meyerhans{at}med-rz.uni-sb.de

The intra-host evolution of 73 human immunodeficiency virus type 1 quasispecies was analysed by split decomposition analysis. Non-synonymous and synonymous nucleotide substitutions were counted along the shortest path connecting all sequences and compared with the numbers expected under the assumption of a random model of mutation. For the majority of substitutions, drift and negative selection seemed to prevail.

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