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Journal of General Virology (2001), 82, 2125-2129.
© 2001 Society for General Microbiology

Animal: RNA Viruses

Differential permissivity to measles virus infection of human and CD46-transgenic murine lymphocytes

Alexey Evlashev1, Hélène Valentin1, Pierre Rivailler1, Olga Azocar1, Chantal Rabourdin-Combe1 and Branka Horvat1,2

INSERM U503, Immunobiologie Fondamentale et Clinique1 and INSERM U404, Immunité et Vaccination, CERVI2, 21 Av. Tony Garnier, 69365 Lyon, France

Author for correspondence: Branka Horvat (at CERVI). Fax +33 437 28 23 91. e-mail horvat{at}cervi-lyon.inserm.fr

Analysis of measles virus (MV) pathogenesis requires the development of an adequate small animal model of MV infection. In this study, permissivity to MV infection was compared in human and transgenic murine T lymphocytes, expressing different levels of the human MV receptor, CD46. Whereas MV binding and entry correlated with CD46 expression, higher levels of MV replication were always observed in human T lymphocytes. This suggests the existence of intracellular factors, acting posterior to virus entry, that could limit MV replication in murine lymphocytes and should be considered when creating new animal models of MV infection.




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S. Vincent, I. Tigaud, H. Schneider, C. J. Buchholz, Y. Yanagi, and D. Gerlier
Restriction of Measles Virus RNA Synthesis by a Mouse Host Cell Line: trans-Complementation by Polymerase Components or a Human Cellular Factor(s)
J. Virol., May 13, 2002; 76(12): 6121 - 6130.
[Abstract] [Full Text] [PDF]


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