| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Animal: RNA Viruses |
Division of Microbiology and Infectious Diseases, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK1
Author for correspondence: Jonathan Ball. Fax +44 115 970 9233. e-mail Jonathan.ball{at}nottingham.ac.uk
Hepatitis C virus (HCV) exists as a complex swarm of genetically related viruses known as a quasispecies. Recent work has shown that quasispecies complexity and evolutionary rates are associated with the outcome of acute infection. Knowledge of how the virus population evolves at different stages of chronic infection is less clear. We have studied rates of evolution of the first hypervariable region (HVR1) of the E2 envelope protein in six individuals with disparate liver disease severity. These data show that virus populations present in individuals with mild non-progressive liver disease evolve in a typical Darwinian fashion, with a consistent accumulation of non-synonymous (amino acid-changing) substitutions. By contrast, the virus population remains relatively static in individuals with severe progressive liver disease. Possible mechanisms for this disparity are discussed.
This article has been cited by other articles:
|
|
 |
|
  M. Torres-Puente, J. M. Cuevas, N. Jimenez-Hernandez, M. A. Bracho, I. Garcia-Robles, F. Carnicer, J. del Olmo, E. Ortega, A. Moya, and F. Gonzalez-Candelas Contribution of insertions and deletions to the variability of hepatitis C virus populations J. Gen. Virol., August 1, 2007; 88(8): 2198 - 2203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Wrobel, M. Torres-Puente, N. Jimenez, M. A. Bracho, I. Garcia-Robles, A. Moya, and F. Gonzalez-Candelas Analysis of the Overdispersed Clock in the Short-Term Evolution of Hepatitis C Virus: Using the E1/E2 Gene Sequences to Infer Infection Dates in a Single Source Outbreak Mol. Biol. Evol., June 1, 2006; 23(6): 1242 - 1253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. P. Brown, V. S. Juttla, A. W. Tarr, R. Finnis, W. L. Irving, S. Hemsley, D. R. Flower, P. Borrow, and J. K. Ball Evolutionary dynamics of hepatitis C virus envelope genes during chronic infection J. Gen. Virol., July 1, 2005; 86(7): 1931 - 1942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Herring, R. Tsui, L. Peddada, M. Busch, and E. L. Delwart Wide Range of Quasispecies Diversity during Primary Hepatitis C Virus Infection J. Virol., April 1, 2005; 79(7): 4340 - 4346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Qin, N. J. Shire, E. D. Keenan, S. D. Rouster, M. E. Eyster, J. J. Goedert, M. J. Koziel, K. E. Sherman, and and the Multicenter Hemophilia Cohort Study Group HCV quasispecies evolution: association with progression to end-stage liver disease in hemophiliacs infected with HCV or HCV/HIV Blood, January 15, 2005; 105(2): 533 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Liu, D. M. Netski, Q. Mao, O. Laeyendecker, J. R. Ticehurst, X.-H. Wang, D. L. Thomas, and S. C. Ray Accurate Representation of the Hepatitis C Virus Quasispecies in 5.2-Kilobase Amplicons J. Clin. Microbiol., September 1, 2004; 42(9): 4223 - 4229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. McKeating, L. Q. Zhang, C. Logvinoff, M. Flint, J. Zhang, J. Yu, D. Butera, D. D. Ho, L. B. Dustin, C. M. Rice, et al. Diverse Hepatitis C Virus Glycoproteins Mediate Viral Infection in a CD81-Dependent Manner J. Virol., August 15, 2004; 78(16): 8496 - 8505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wodarz Hepatitis C virus dynamics and pathology: the role of CTL and antibody responses J. Gen. Virol., July 1, 2003; 84(7): 1743 - 1750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ayers, K. Siu, E. Roberts, A. M. Garvin, and R. Tellier Characterization of Hepatitis C Virus Quasispecies by Matrix-Assisted Laser Desorption Ionization-Time of Flight (Mass Spectrometry) Mutation Detection J. Clin. Microbiol., September 1, 2002; 40(9): 3455 - 3462. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
