| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Animal: DNA Viruses |
The Children’s Hospital of Philadelphia, Division of Immunologic and Infectious Diseases, Abramson 1202, 3516 Civic Center Boulevard, Philadelphia, PA 19104, USA1
The Wistar Institute, Philadelphia, PA 19104, USA2
The Institute for Human Gene Therapy, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA3
Author for correspondence: Christopher Cohen. Fax +1 215 590 2025. e-mail Cohenc{at}email.chop.edu
A replication-defective form of chimpanzee adenovirus type 68 (C68) has been developed to circumvent problems posed by widespread preexisting immunity to common human adenovirus vectors. To investigate the determinants of C68 tropism, its interaction with the coxsackievirus and adenovirus receptor (CAR) was studied. Although CHO cells were resistant to transduction by C68 as well as by adenovirus type 5 (Ad5), CHO cells expressing either human or murine CAR were transduced readily. C68 transduction, like Ad5 transduction, was blocked when cells were exposed to anti-CAR antibody or when virus was exposed to a soluble form of the CAR extracellular domain. These results indicate that gene delivery by C68 occurs by a CAR-dependent mechanism.
This article has been cited by other articles:
|
|
 |
|
  N. Tatsis, M. O. Lasaro, S.-W. Lin, Z. Q. Xiang, D. Zhou, L. DiMenna, H. Li, A. Bian, S. Abdulla, Y. Li, et al. Adenovirus Vector-Induced Immune Responses in Nonhuman Primates: Responses to Prime Boost Regimens J. Immunol., May 15, 2009; 182(10): 6587 - 6599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sridhar, A. Reyes-Sandoval, S. J. Draper, A. C. Moore, S. C. Gilbert, G. P. Gao, J. M. Wilson, and A. V. S. Hill Single-Dose Protection against Plasmodium berghei by a Simian Adenovirus Vector Using a Human Cytomegalovirus Promoter Containing Intron A J. Virol., April 15, 2008; 82(8): 3822 - 3833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Havenga, R. Vogels, D. Zuijdgeest, K. Radosevic, S. Mueller, M. Sieuwerts, F. Weichold, I. Damen, J. Kaspers, A. Lemckert, et al. Novel replication-incompetent adenoviral B-group vectors: high vector stability and yield in PER.C6 cells. J. Gen. Virol., August 1, 2006; 87(Pt 8): 2135 - 2143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Hensley, W. Giles-Davis, K. C. McCoy, W. Weninger, and H. C. J. Ertl Dendritic Cell Maturation, but Not CD8+ T Cell Induction, Is Dependent on Type I IFN Signaling during Vaccination with Adenovirus Vectors J. Immunol., November 1, 2005; 175(9): 6032 - 6041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang and J. M. Bergelson Adenovirus Receptors J. Virol., October 1, 2005; 79(19): 12125 - 12131. [Full Text] [PDF]
|
|
|
|
|
|
Z. Q. Xiang, G. P. Gao, A. Reyes-Sandoval, Y. Li, J. M. Wilson, and H. C. J. Ertl Oral Vaccination of Mice with Adenoviral Vectors Is Not Impaired by Preexisting Immunity to the Vaccine Carrier J. Virol., October 15, 2003; 77(20): 10780 - 10789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Fitzgerald, G.-P. Gao, A. Reyes-Sandoval, G. N. Pavlakis, Z. Q. Xiang, A. P. Wlazlo, W. Giles-Davis, J. M. Wilson, and H. C. J. Ertl A Simian Replication-Defective Adenoviral Recombinant Vaccine to HIV-1 Gag J. Immunol., February 1, 2003; 170(3): 1416 - 1422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Petrella, C. J. Cohen, J. Gaetz, and J. M. Bergelson A Zebrafish Coxsackievirus and Adenovirus Receptor Homologue Interacts with Coxsackie B Virus and Adenovirus J. Virol., September 11, 2002; 76(20): 10503 - 10506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.-P. Gao, M. R. Alvira, L. Wang, R. Calcedo, J. Johnston, and J. M. Wilson Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy PNAS, September 3, 2002; 99(18): 11854 - 11859. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
