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Detection of quantitative trait loci for resistance/susceptibility to pseudorabies virus in swine

Department of Animal Breeding and Biotechnology, University of Hohenheim, Garbenstraße 17, D-70593 Stuttgart, Germany¹
Federal Research Centre for Virus Diseases of Animals, D-72076 Tübingen, Germany²

Author for correspondence: Gerald Reiner. Present address: Professur für Schweinekrankheiten, Justus-Liebig-Universität Giessen, Frankfurter Strasse 112, D-35392 Giessen, Germany. Fax +49 641 201854. e-mail gerald.reiner{at}vetmed.uni-giessen.de

This study describes genetic differences in resistance/susceptibility to pseudorabies virus (PrV) between European Large White and Chinese Meishan pigs, with a mapping of quantitative trait loci (QTL) obtained from a genome-wide scan in F₂ animals. Eighty-nine F₂ pigs were challenged intranasally at 12 weeks with 10⁵ p.f.u. of the wild-type PrV strain NIA-3. For QTL analysis, 85 microsatellite markers, evenly spaced on the 18 porcine autosomes and on the pseudoautosomal region of the X chromosome, were genotyped. All pigs developed clinical signs, i.e. fever, from 3 to 7 days p.i. The pure-bred Large White pigs, the F₁ and three-quarters of the F₂ animals, but none of the Meishan pigs, developed neurological symptoms and died or were euthanized. QTLs for appearance/non-appearance of neurological symptoms were found on chromosomes 9, 5, 6 and 13. They explained 10·6–17·9% of F₂ phenotypic variance. QTL effects for rectal temperature after PrV challenge were found on chromosomes 2, 4, 8, 10, 11 and 16. Effects on chromosomes 9, 10 and 11 were significant on a genome-wide level. The results present chromosomal regions that are associated with presence/absence of neurological symptoms as well as temperature course after intranasal challenge with NIA-3. The QTLs are in proximity to important candidate genes that are assumed to play crucial roles in host defence against PrV.

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