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Journal of General Virology (2002), 83, 2485-2488.
© 2002 Society for General Microbiology

Animal: RNA Viruses

Detection of measles virus genome in bone-marrow aspirates from adults

Satomi Sonoda1,3, Mitsuo Kitahara2 and Tetsuo Nakayama3

Department of Pediatrics, School of Medicine, Keio University, Shinano-Machi 35, Shinjyuku-ku, Tokyo 160-8582, Japan1
Department of Internal Medicine, Saiseikai Central Hospital, Mita 1-4-17, Minato-ku, Tokyo 108-0073, Japan2
Laboratory of Viral Infection, Kitasato Institute for Life Sciences, Shirokane 5-9-1, Minato-ku Tokyo 108-8641, Japan3

Author for correspondence: Tetsuo Nakayama. Fax +81 3 5791 6130. e-mail tetsuon{at}lisci.kitasato-u.ac.jp

We investigated the presence of the measles virus genome in order to identify asymptomatic infections in the adult population. Bone-marrow aspirates were obtained from 179 patients, 20–96 years of age, for the diagnosis of malignant diseases (29 with malignant lymphoma, 28 with acute leukaemia, 21 with myelodysplastic syndrome, five with multiple myeloma and 96 with other diseases). The measles virus genome was detected in 17 (9·5%) of 179 individuals by RT–PCR and 28 (15·6%) through hybridization. The genomes detected in bone marrow were all in the same cluster, D5, the strain circulating during the study period, and no evidence of persistent infection was obtained. We conclude that asymptomatic infections of measles virus are common in adults and the presence of the measles virus genome would not be related to the pathogenesis of illness.






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