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Journal of General Virology (2002), 83, 2489-2496.
© 2002 Society for General Microbiology

Animal: RNA Viruses

Antigenic relationships between six genotypes of the small hydrophobic protein gene of mumps virus

Claes Örvell1, Tesfaldet Tecle1, Bo Johansson1, Hiroyuki Saito2 and Agneta Samuelson1

Huddinge University Hospital, Department of Clinical Virology, Karolinska Institutet, SE-141 86 Stockholm, Sweden1
Department of Microbiology, Akita Prefectural Institute of Public Health, Akita 010-0874, Japan2

Author for correspondence: Claes Örvell. Fax +46 8 58 58 13 05. e-mail clor{at}labd01.hs.sll.se

Six different genotypes of mumps virus, A, C, D, G, H and I, genotyped on the basis of the small hydrophobic protein gene sequence, were subjected to antigenic comparison. Monoclonal antibodies directed against the haemagglutinin–neuraminidase protein of the SBL-1 strain of genotype A were used in immunofluorescence tests with different mumps virus strains. In addition, the six virus genotypes were compared by cross-neutralization tests with human post-vaccination sera after vaccination with the Jeryl Lynn (JL) strain of mumps virus and with rabbit hyperimmune sera directed against the A or D genotypes of mumps virus. Genotypes C, D, G, H and I could not be antigenically separated. In contrast, three different virus strains of genotype A, SBL-1, JL and Kilham, were distinct and were found to represent three different serotypes within the A genotype of mumps virus. Vaccination of Swedish children with the JL strain of mumps virus resulted in clearly lower neutralization titres against the SBL-1 strain, which is endemic in Sweden, compared to the homologous vaccine titres.




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