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Journal of General Virology (2002), 83, 2607-2616.
© 2002 Society for General Microbiology

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PrPSc accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission

Olivier Andréoletti1, Caroline Lacroux1, Armelle Chabert1, Laurent Monnereau1, Guillaume Tabouret1, Frédéric Lantier2, Patricia Berthon2, Francis Eychenne3, Sylvie Lafond-Benestad4, Jean-Michel Elsen5 and François Schelcher1

UMR 959 INRA-ENVT, Physiopathologie Infectieuse et Parasitaire des Ruminants, Ecole Nationale Vétérinaire, 23 Chemin des Capelles, 31076 Toulouse Cedex 3, France1
INRA, Laboratoire de Pathologie Infectieuse et Immunologie, Nouzilly, France2
INRA, Domaine de Langlade, Pompertuzat, France3
NVI, Department of Pathology, Oslo, Norway4
INRA, Station d’Amélioration Génétique des Animaux, Auzeville, France5

Author for correspondence: Olivier Andréoletti. Fax +33 5 61 19 38 34. e-mail o.andreoletti{at}envt.fr

Placentas from scrapie-affected ewes are known to be infectious. Nevertheless, placenta infectivity in such ewes is not systematic. Maternal transmission to lambs is highly suspected but contamination of the foetus in utero has not been demonstrated. Using ewes from a naturally scrapie-infected flock, it was demonstrated that abnormal prion protein (PrPSc) accumulation in the placenta (i) is controlled by polymorphisms at codons 136, 154 and 171 of the foetal PrP gene and (ii) is restricted mainly to placentome foetal trophoblastic cells. In order to go deeper into the role of the placenta in scrapie transmission, the pattern of PrPSc dissemination was established in susceptible lambs (genotype VRQ/VRQ) sampled from 140 days post-insemination to the age of 4 months from either VRQ/VRQ ewes with PrPSc-positive placentas or ARR/VRQ ewes with PrPSc-negative placentas. In both VRQ/VRQ lamb groups, PrPSc spatial and temporal accumulation patterns were similar, suggesting post-natal rather than in utero contamination.




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