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Canine vaccine recipients recognize an immunodominant region of the rabies virus glycoprotein

Rabies Research and Diagnostic Group, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey KT15 3NB, UK¹

Author for correspondence: Nicholas Johnson. Fax +44 1932 347046. e-mail n.johnson2{at}vla.defra.gsi.gov.uk

To investigate the immune response to anti-rabies vaccination in the principal recipient (the domestic dog), four truncated fragments of the rabies virus glycoprotein were expressed as glutathione S-transferase fusion proteins. Immune sera from vaccinated rabbits and dogs were then used to probe for reactivity with these expressed proteins. In two rabbits and four dogs tested, the dominant antibody response to non-conformational antigenic sites appeared to be directed to a region of the glycoprotein between amino acids 222 and 332. The N-terminal fragment of the glycoprotein was also significantly antigenic. Further studies to assess whether the antibody response to the internal domain could neutralize the rabies Challenge Virus Standard (CVS) strain, using antibody depletion, suggested that this fraction did contribute to the ability of post-vaccination sera to neutralize and therefore protect against infection.

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