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Journal of General Virology (2002), 83, 439-442.
© 2002 Society for General Microbiology

Animal: RNA Viruses

Fv1-like restriction of N-tropic replication-competent murine leukaemia viruses in mCAT-1-expressing human cells

Lars Aagaard1, Jacob Giehm Mikkelsena,1, Søren Warming1, Mogens Duch1 and Finn Skou Pedersen1,2

Department of Molecular and Structural Biology1, Department of Medical Microbiology and Immunology2, C. F. Moellers Allé, Bldg 130, DK-8000 Aarhus, University of Aarhus, Denmark

Author for correspondence: Finn Skou Pedersen. Fax +45 86196500. e-mail fsp{at}mbio.aau.dk

To study the replication of murine leukaemia viruses in human cells we have used full-length as well as EGFP-tagged ecotropic viruses in combination with mCAT-1-expressing human cells. We present results showing that N-tropic murine leukaemia viruses are restricted in both infection and replication in such cells while B-tropic viruses, modified at capsid position 110, escape restriction. These results support a recently reported Fv1-like restriction in mammalian cells. We extend the analysis of Fv1-like restriction by demonstrating that NB-tropic viruses also escape restriction and human mCAT-1-expressing cells are thus similar to murine Fv1b cells with respect to infection though the ecotropic receptor pathway.




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