| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Animal: DNA Viruses |
receptor is a homodimer
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK1
Author for correspondence: Geoffrey L. Smith. Present address: The Wright–Fleming Institute, Imperial College School of Medicine, St Mary’s Campus, Norfolk Place, London W2 1PG, UK. Fax +44 207 594 3973. e-mail glsmith{at}ic.ac.uk
The vaccinia virus (VV) interferon (IFN)-
receptor (IFN-R) is a 43 kDa soluble glycoprotein that is secreted from infected cells early during infection. Here we demonstrate that the IFN-R from VV, cowpox virus and camelpox virus exists naturally as a homodimer, whereas the cellular IFN-R dimerizes only upon binding the homodimeric IFN-. The existence of the virus protein as a dimer in the absence of ligand may provide an advantage to the virus in efficient binding and inhibition of IFN- in solution.
This article has been cited by other articles:
|
|
 |
|
  A. A. Nuara, L. J. Walter, N. J. Logsdon, S. I. Yoon, B. C. Jones, J. M. Schriewer, R. M. Buller, and M. R. Walter Structure and mechanism of IFN-{gamma} antagonism by an orthopoxvirus IFN-{gamma}-binding protein PNAS, February 12, 2008; 105(6): 1861 - 1866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Ahmed, J. P. Martin, and H. M. Johnson IFN Mimetic as a Therapeutic for Lethal Vaccinia Virus Infection: Possible Effects on Innate and Adaptive Immune Responses J. Immunol., April 1, 2007; 178(7): 4576 - 4583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Nuara, H. Bai, N. Chen, R. M. L. Buller, and M. R. Walter The Unique C Termini of Orthopoxvirus Gamma Interferon Binding Proteins Are Essential for Ligand Binding J. Virol., November 1, 2006; 80(21): 10675 - 10682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. I. Ahmed, M. A. Burkhart, P. S. Subramaniam, M. G. Mujtaba, and H. M. Johnson Peptide Mimetics of Gamma Interferon Possess Antiviral Properties against Vaccinia Virus and Other Viruses in the Presence of Poxvirus B8R Protein J. Virol., May 1, 2005; 79(9): 5632 - 5639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Reading and G. L. Smith Vaccinia Virus Interleukin-18-Binding Protein Promotes Virulence by Reducing Gamma Interferon Production and Natural Killer and T-Cell Activity J. Virol., September 15, 2003; 77(18): 9960 - 9968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Johnston and G. McFadden Poxvirus Immunomodulatory Strategies: Current Perspectives J. Virol., June 1, 2003; 77(11): 6093 - 6100. [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Reading, J. B. Moore, and G. L. Smith Steroid Hormone Synthesis by Vaccinia Virus Suppresses the Inflammatory Response to Infection J. Exp. Med., May 19, 2003; 197(10): 1269 - 1278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Symons, E. Adams, D. C. Tscharke, P. C. Reading, H. Waldmann, and G. L. Smith The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model J. Gen. Virol., November 1, 2002; 83(11): 2833 - 2844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Symons, D. C. Tscharke, N. Price, and G. L. Smith A study of the vaccinia virus interferon-{gamma} receptor and its contribution to virus virulence J. Gen. Virol., August 1, 2002; 83(8): 1953 - 1964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Tscharke, P. C. Reading, and G. L. Smith Dermal infection with vaccinia virus reveals roles for virus proteins not seen using other inoculation routes J. Gen. Virol., August 1, 2002; 83(8): 1977 - 1986. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
