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Journal of General Virology (2002), 83, 801-805.
© 2002 Society for General Microbiology

Animal: RNA Viruses

Sustained G->A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome

Jean-Pierre Vartanian1, Michel Henry1 and Simon Wain-Hobson1

Unité de Rétrovirologie Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France1

Author for correspondence: Simon Wain-Hobson. Fax +33 1 45 68 88 74. e-mail simon{at}pasteur.fr

Two full-length human immunodeficiency virus type 1 O sequences are described, one of which was hypermutated in all regions of the genome. This indicates that the intracellular [dTTP]/[dCTP] bias conducive to G->A hypermutation may be sustained throughout the synthesis of minus-strand DNA. In turn, this suggests the possibility of mutation of host sequences.




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