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Journal of General Virology (2002), 83, 1613-1619.
© 2002 Society for General Microbiology

Animal: DNA Viruses

Mixed patterns of transmission of human herpesvirus-8 (Kaposi’s sarcoma-associated herpesvirus) in Malawian families

Rachelle D. Cook1,2, Tim A. Hodgson1, Alastair C. W. Waughb,1, Elizabeth M. Molyneux3, Eric Borgstein4, A. Sherry4, Chong Gee Teo2 and Stephen R. Porter1

Department of Oral Medicine, Eastman Dental Institute for Oral Health Care Sciences, UCL, University of London, UK1
Virus Reference Division, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT, UK2
Department of Paediatrics3 and Department of Surgery4, College of Medicine, University of Malawi, Blantyre, Malawi

Author for correspondence: Rachelle Cook (at the Virus Reference Division). Fax +44 208 200 1569. e-mail rcook{at}phls.org.uk

To study transmission patterns of human herpesvirus-8 (HHV-8) (Kaposi’s sarcoma-associated herpesvirus) in families in Malawi, nucleotide sequences derived from two hypervariable loci of the HHV-8 genome, the V1 and V2 regions of open reading frame K1 (K1/V1 and K1/V2, respectively), were amplified from blood and mouth rinse samples of 22 patients with treated and untreated Kaposi’s sarcoma (KS) and their first-degree relatives (n=67). In patients with KS, vincristine therapy was significantly associated with non-detectability of circulating, but not oral, K1/V1 DNA. Intra-familial K1/V1 phylogenetic comparisons of eight families were possible. Both identical and non-identical sequences were observed between family members, suggesting transmission of HHV-8 along both intra- and extra-familial transmission routes.




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