J Gen Virol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bharadwaj, M.
Right arrow Articles by Hjelle, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bharadwaj, M.
Right arrow Articles by Hjelle, B.
Agricola
Right arrow Articles by Bharadwaj, M.
Right arrow Articles by Hjelle, B.
Journal of General Virology (2002), 83, 1745-1751.
© 2002 Society for General Microbiology

Animal: RNA Viruses

Genetic vaccines protect against Sin Nombre hantavirus challenge in the deer mouse (Peromyscus maniculatus)

Mausumi Bharadwaj1, Katy Mirowsky1, Chunyan Ye1, Jason Botten1, Barbara Masten1, Joyce Yee1, C. Richard Lyons2 and Brian Hjelle1,3

Center for Emerging Infectious Diseases, Departments of Pathology1, Medicine2 and Biology and Molecular Genetics and Microbiology3, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA

Author for correspondence: Brian Hjelle (at Department of Pathology). Fax +1 505 272 9912. e-mail bhjelle{at}salud.unm.edu

We used a deer mouse (Peromyscus maniculatus) infection model to test the protective efficacy of genetic vaccine candidates for Sin Nombre (SN) virus that were known to provoke immunological responses in BALB/c mice (Bharadwaj et al., Vaccine 17, 2836–2843, 1999 ). Protective epitopes were localized in each of four overlapping cDNA fragments that encoded portions of the SN virus G1 glycoprotein antigen; the nucleocapsid gene also was protective. The protective efficacy of glycoprotein gene fragments correlated with splenocyte proliferation in the presence of cognate antigen, but none induced neutralizing antibodies. Genetic vaccines against SN virus can protect outbred deer mice from infection even in the absence of a neutralizing antibody response.




This article has been cited by other articles:


Home page
 J. Virol.Home page
D. Safronetz, N. R. Hegde, H. Ebihara, M. Denton, G. P. Kobinger, S. St. Jeor, H. Feldmann, and D. C. Johnson
Adenovirus Vectors Expressing Hantavirus Proteins Protect Hamsters against Lethal Challenge with Andes Virus
J. Virol., July 15, 2009; 83(14): 7285 - 7295.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Schountz, J. Prescott, A. C. Cogswell, L. Oko, K. Mirowsky-Garcia, A. P. Galvez, and B. Hjelle
Regulatory T cell-like responses in deer mice persistently infected with Sin Nombre virus
PNAS, September 25, 2007; 104(39): 15496 - 15501.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
R. A. Medina, K. Mirowsky-Garcia, J. Hutt, and B. Hjelle
Ribavirin, human convalescent plasma and anti-beta3 integrin antibody inhibit infection by Sin Nombre virus in the deer mouse model
J. Gen. Virol., February 1, 2007; 88(2): 493 - 505.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
D. M. Custer, E. Thompson, C. S. Schmaljohn, T. G. Ksiazek, and J. W. Hooper
Active and Passive Vaccination against Hantavirus Pulmonary Syndrome with Andes Virus M Genome Segment-Based DNA Vaccine
J. Virol., September 15, 2003; 77(18): 9894 - 9905.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2002 by the Society for General Microbiology.