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Absence of canine oral papillomavirus DNA following prophylactic L1 particle-mediated immunotherapeutic delivery vaccination

Department of Pathology, Cambridge University, Cambridge CB2 1QP, UK¹
Glaxo Smithkline Research and Development, Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, UK²

Author for correspondence: Richard Moore. Fax +44 1223 333730. e-mail ram36{at}cam.ac.uk

In the canine oral papillomavirus (COPV) model, following wart regression, COPV DNA was detected by PCR at the challenge site. However, following particle-mediated immunotherapeutic delivery (PMID) of COPV L1 and subsequent challenge, no COPV DNA could be detected. These data support PMID of COPV L1 as a protective vaccine and suggest that PMID of L1 may induce virus clearance.

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				M. Stanley Chapter 17: Genital Human Papillomavirus Infections--Current and Prospective Therapies J Natl Cancer Inst Monographs, June 1, 2003; 2003(31): 117 - 124. [Abstract] [Full Text] [PDF]