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Staphylococcus aureus Strain DU4916 -- an Atypical Methicillin-resistant Isolate?

Department of Bacteriology, University of Bristol, Bristol BS8 1TD

ABSTRACT

SUMMARY: Staphylococcus aureus strain DU4916 was examined for linkage of markers. No ‘curing’ action due to treatment with acridine dyes was demonstrated. The genes for penicillinase production and metal-ion resistance (borne by a plasmid of 20 x 10⁶ daltons), tetracycline resistance (a plasmid of 2·9 x 10⁶), streptomycin resistance (a chromosomal gene) and methicillin resistance (of uncertain locus) were separately transduced to recipients. No linkage of methicillin resistance with enterotoxin B, haemolysins, pigment, or a gene that suppresses inducible resistance to erythromycin was demonstrated. These data are consistent with the hypothesis that all methicillin-resistant strains of S. aureus have a common and relatively recent origin.

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