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J Gen Virol 84 (2003), 2729-2734; DOI 10.1099/vir.0.19284-0

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© 2003 Society for General Microbiology

Recombination analysis of human-tropic porcine endogenous retroviruses

Nikolai Klymiuk1,2, Mathias Müller2, Gottfried Brem1,3 and Bernhard Aigner1,2,{dagger}

1 ApoGene Biotechnologie, D-86567 Hilgertshausen, Germany
2 Institut für Tierzucht und Genetik, Veterinärmedizinische Universität Wien, A-1210 Vienna, Austria
3 Ludwig-Boltzmann-Institut für Immuno-, Zyto- und Molekulargenetische Forschung Wien, A-1210 Vienna, Austria

Correspondence
Bernhard Aigner
b.aigner{at}gen.vetmed.uni-muenchen.de

Prevention of cross-species infection of porcine endogenous retroviruses (PERV) is crucial for xenotransplantation. The potential risk of infection is caused by replication-competent PERV as well as by hybrid viruses derived from recombination events of distinct PERV genomes. Recently, human-tropic, replication-competent PERV genomes obtaining hybrid sequences have been observed. Here, complete polymorphism pattern analysis was performed on the full-length PERV {gamma}1 clones and on the complete envelope (env) gene sequences published to date. Several recombined full-length clones and a high number of different recombination patterns in the env gene were identified. In addition, recombinations with retroviral genomes not yet known were found. Thus, the potential risk of infection also exists for recombination products, including defective PERV loci.

{dagger}Present address: Lehrstuhl für Molekulare Tierzucht und Biotechnologie, Moorversuchsgut, Hackerstr. 27, D-85764 Oberschleißheim, Germany




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