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Cholesterol-dependent infection of Burkitt's lymphoma cell lines by Epstein–Barr virus

Department of Microbiology-Immunology, Northwestern University Medical School Chicago, IL 60611, USA

Correspondence
Richard Longnecker
r-longnecker{at}northwestern.edu

Epstein–Barr virus (EBV) infection is a multi-step process, first requiring virus binding to the host cell, followed by fusion of the viral envelope with the host cell plasma membrane. Efficient EBV entry into B cells requires, at the minimum, the interaction of the EBV-encoded glycoproteins gp350 with cellular CD21 and gp42 with MHC class II proteins. In this study, use of the cholesterol-binding drugs methyl--cyclodextrin and nystatin efficiently inhibited EBV infection of target Burkitt's lymphoma B-cell lines, indicating an important role for cholesterol and suggesting the involvement of lipid rafts in EBV infection.

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