HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Phumiamorn, S. Articles by Shiraki, K. Search for Related Content PubMed PubMed Citation Articles by Phumiamorn, S. Articles by Shiraki, K. Agricola Articles by Phumiamorn, S. Articles by Shiraki, K.

Induction of humoral and cell-mediated immunity to hepatitis B surface antigen by a novel adjuvant activity of Oka varicella vaccine

Department of Virology, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan

Correspondence
Kimiyasu Shiraki
kshiraki{at}toyama-mpu.ac.jp

Oka varicella vaccine induces humoral and cell-mediated immunity to varicella-zoster virus (VZV), even in immunocompromised hosts. This vaccine showed novel adjuvant activity against co-inoculated hepatitis B surface antigen (HBsAg). Either a mixed inoculation of HBsAg with heat-inactivated Oka varicella vaccine at one site or a separate inoculation of HBsAg and live vaccine at different sites induced an antibody response but failed to induce delayed type hypersensitivity (DTH) to HBsAg. In contrast, immunization of HBsAg mixed with live vaccine induced DTH and an enhanced antibody response to HBsAg. The adjuvant activity of Oka varicella vaccine was similar in terms of antibody production to that of alum adjuvant. A T helper cell-dominant immunity to VZV and HBsAg continued for 1 year. Oka varicella vaccine combined with a foreign antigen may serve as a novel polyvalent vaccine for the infectious diseases for which cell-mediated immunity is beneficial.

This article has been cited by other articles:

				T. M. Ward, V. Traina-Dorge, K. A. Davis, and W. L. Gray Recombinant simian varicella viruses expressing respiratory syncytial virus antigens are immunogenic J. Gen. Virol., March 1, 2008; 89(3): 741 - 750. [Abstract] [Full Text] [PDF]

				A. S. Hidmark, E. K. L. Nordstrom, P. Dosenovic, M. N. E. Forsell, P. Liljestrom, and G. B. Karlsson Hedestam Humoral Responses against Coimmunized Protein Antigen but Not against Alphavirus-Encoded Antigens Require Alpha/Beta Interferon Signaling J. Virol., July 15, 2006; 80(14): 7100 - 7110. [Abstract] [Full Text] [PDF]

				J. M. Thompson, A. C. Whitmore, J. L. Konopka, M. L. Collier, E. M. B. Richmond, N. L. Davis, H. F. Staats, and R. E. Johnston Mucosal and systemic adjuvant activity of alphavirus replicon particles PNAS, March 7, 2006; 103(10): 3722 - 3727. [Abstract] [Full Text] [PDF]

				C. L. Hutchings, S. C. Gilbert, A. V. S. Hill, and A. C. Moore Novel Protein and Poxvirus-Based Vaccine Combinations for Simultaneous Induction of Humoral and Cell-Mediated Immunity J. Immunol., July 1, 2005; 175(1): 599 - 606. [Abstract] [Full Text] [PDF]