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Absence of a functional defect in CD8⁺ T cells during primary murine gammaherpesvirus-68 infection of I-A^b-/- mice

Gabrielle T. Belz

Philip G. Stevenson

Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA

Correspondence
Philip Stevenson (at University of Cambridge)
pgs27{at}mole.bio.cam.ac.uk

The murine gammaherpesvirus-68 kills I-A^b-/- mice despite the presence of virus-specific CD8⁺ cytotoxic T lymphocytes (CTL). This has raised the possibility that these CTL are functionally abnormal. Here, no difference was observed between I-A^b-/- mice and I-A^b+/+ controls in virus-specific CTL function, T cell receptor usage, or surface phenotype. Thus CTL immunity was independent of CD4⁺ T cells in a chronic herpesvirus infection, but was still inadequate to control virus replication.

Present address: Division of Immunology, Walter and Eliza Hall Institute of Medical Research, PO Box Royal Melbourne Hospital, Victoria 3050, Australia.

Present address: Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

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