| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Correspondence
Susanna Twiddy
susanna.twiddy{at}zoo.ox.ac.uk
The family Flaviviridae includes important human pathogens, such as dengue (DEN) virus, yellow fever (YF) virus and hepatitis C virus, many of which have emerged or re-emerged in recent years. Until recently, flavivirus evolution was thought to proceed in a clonal manner, with diversity generated mainly through the accumulation of mutational changes. However, this assumption has now been shown to be invalid, with homologous recombination demonstrated in all three genera of the Flaviviridae. Since recombination has important implications for the study of virus evolution, a survey of recombination in the viruses of the genus Flavivirus was carried out. Using envelope gene sequence data and a combination of graphical and phylogenetic analyses, hitherto unreported recombination in Japanese encephalitis virus and St Louis encephalitis virus was detected, as well as further recombinants in DEN virus. However, no evidence for recombination was found in West Nile or YF viruses, or in the tick-borne flavivirus group. It is proposed that the difference between the mosquito- and tick-borne viruses can be accounted for by their differing modes of transmission, whilst the variation among the mosquito-borne flaviviruses reflects both the ecology of the particular host and vector species and also bias in the sampling process.
This article has been cited by other articles:
|
|
 |
|
  C. Taucher, A. Berger, and C. W. Mandl A trans-Complementing Recombination Trap Demonstrates a Low Propensity of Flaviviruses for Intermolecular Recombination J. Virol., January 1, 2010; 84(1): 599 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. May, L. Li, S. Zhang, H. Guzman, D. W. C. Beasley, R. B. Tesh, S. Higgs, P. Raj, R. Bueno Jr, Y. Randle, et al. Genetic variation of St. Louis encephalitis virus J. Gen. Virol., August 1, 2008; 89(8): 1901 - 1910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Raviprakash, D. Wang, D. Ewing, D. H. Holman, K. Block, J. Woraratanadharm, L. Chen, C. Hayes, J. Y. Dong, and K. Porter A Tetravalent Dengue Vaccine Based on a Complex Adenovirus Vector Provides Significant Protection in Rhesus Monkeys against All Four Serotypes of Dengue Virus J. Virol., July 15, 2008; 82(14): 6927 - 6934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Ciota, K. A. Ngo, A. O. Lovelace, A. F. Payne, Y. Zhou, P.-Y. Shi, and L. D. Kramer Role of the mutant spectrum in adaptation and replication of West Nile virus J. Gen. Virol., March 1, 2007; 88(3): 865 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Simmonds Recombination and Selection in the Evolution of Picornaviruses and Other Mammalian Positive-Stranded RNA Viruses J. Virol., November 15, 2006; 80(22): 11124 - 11140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Noppornpanth, T. X. Lien, Y. Poovorawan, S. L. Smits, A. D. M. E. Osterhaus, and B. L. Haagmans Identification of a Naturally Occurring Recombinant Genotype 2/6 Hepatitis C Virus J. Virol., August 1, 2006; 80(15): 7569 - 7577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Domingo, G. Palacios, O. Jabado, N. Reyes, M. Niedrig, J. Gascon, M. Cabrerizo, W. I. Lipkin, and A. Tenorio Use of a Short Fragment of the C-Terminal E Gene for Detection and Characterization of Two New Lineages of Dengue Virus 1 in India J. Clin. Microbiol., April 1, 2006; 44(4): 1519 - 1529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rohayem, J. Munch, and A. Rethwilm Evidence of Recombination in the Norovirus Capsid Gene J. Virol., April 15, 2005; 79(8): 4977 - 4990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Bryant, P. F. C. Vasconcelos, R. C. A. Rijnbrand, J. P. Mutebi, S. Higgs, and A. D. T. Barrett Size Heterogeneity in the 3' Noncoding Region of South American Isolates of Yellow Fever Virus J. Virol., March 15, 2005; 79(6): 3807 - 3821. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Kalinina, H. Norder, and L. O. Magnius Full-length open reading frame of a recombinant hepatitis C virus strain from St Petersburg: proposed mechanism for its formation J. Gen. Virol., July 1, 2004; 85(7): 1853 - 1857. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Leh-Louis, B. Wirth, L. Despons, S. Wain-Hobson, S. Potier, and J. L. Souciet Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and implication of recombination in phylogeny Nucleic Acids Res., April 15, 2004; 32(7): 2069 - 2078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Colina, D. Casane, S. Vasquez, L. Garcia-Aguirre, A. Chunga, H. Romero, B. Khan, and J. Cristina Evidence of intratypic recombination in natural populations of hepatitis C virus J. Gen. Virol., January 1, 2004; 85(1): 31 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. N. Bennett, E. C. Holmes, M. Chirivella, D. M. Rodriguez, M. Beltran, V. Vorndam, D. J. Gubler, and W. O. McMillan Selection-Driven Evolution of Emergent Dengue Virus Mol. Biol. Evol., October 1, 2003; 20(10): 1650 - 1658. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
