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J Gen Virol 84 (2003), 567-572; DOI 10.1099/vir.0.18654-0

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© 2003 Society for General Microbiology

Short Communication

Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus

Mario Lobigs, Arno Müllbacher, Yang Wang, Megan Pavy and Eva Lee

Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, PO Box 334, Canberra, ACT 2601, Australia

Correspondence
Mario Lobigs
Mario.Lobigs{at}anu.edu.au

We have investigated the contribution of the interferon (IFN)-{alpha}/{beta} system, IFN-{gamma} and nitric oxide to recovery from infection with Murray Valley encephalitis virus, using a mouse model for flaviviral encephalitis where a small dose of virus was administered to 6-week-old wild-type and gene knockout animals by the intravenous route. We show that a defect in the IFN-{alpha}/{beta} responses results in uncontrolled extraneural virus growth, rapid virus entry into the brain and 100 % mortality. In contrast, mice deficient in IFN-{gamma} or nitric oxide production display an only marginally increased susceptibility to infection with the neurotropic virus.




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