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J Gen Virol 84 (2003), 603-606; DOI 10.1099/vir.0.18645-0

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© 2003 Society for General Microbiology

Short Communication

A functional genetic approach suggests a novel interaction between the human immunodeficiency virus type 1 (HIV-1) Tat protein and HIV-1 TAR RNA in vivo

Lars H. Lund1,2,3,{dagger}, Britta Wahren3 and Mariano A. Garcia-Blanco1,2

1 Departments of Molecular Genetics and Microbiology, Duke University Medical Center, Box 3053 (424 CARL), Research Drive, Durham, NC 27710, USA
2 Medicine, Duke University Medical Center, Box 3053 (424 CARL), Research Drive, Durham, NC 27710, USA
3 Microbiology and Tumor Biology Center and Swedish Institute for Infectious Disease Control, Karolinska Institute, Solna 17182, Sweden

Correspondence
Mariano Garcia-Blanco
garci001{at}mc.duke.edu

Human immunodeficiency virus type 1 (HIV-1) Tat and human Cyclin T1 form a complex and together recognize the viral TAR RNA element with specificity. Using HIV-1/equine infectious anaemia virus TAR chimeras, we show that in addition to the well-characterized interaction with the bulge, Tat recognizes the distal stem and the loop of TAR. These data support previously proposed, but unproven, molecular models.

{dagger}Present address: Columbia University College of Physicians & Surgeons, Department of Medicine, 630 W 168th Street, New York, NY 10032, USA.




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H. HUTHOFF, F. GIRARD, S. S. WIJMENGA, and B. BERKHOUT
Evidence for a base triple in the free HIV-1 TAR RNA
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[Abstract] [Full Text] [PDF]


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