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Oral immunization with recombinant Yersinia enterocolitica expressing a measles virus CD4 T cell epitope protects against measles virus-induced encephalitis

¹ Institut für Virologie und Immunbiologie, Versbacher Str. 7, 97078 Würzburg, Germany
² Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, München, Germany

Correspondence
Stefan Niewiesk
niewiesk{at}vim.uni-wuerzburg.de

Immunization via the oral route with an attenuated Yersinia enterocolitica strain expressing a fragment of the measles virus nucleocapsid protein (aa 79–161) via its type III protein secretion system induced a T helper type 1 response in immunized C3H mice, which conferred protection against measles virus-induced encephalitis in a time- and dose-dependent manner.

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