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J Gen Virol 84 (2003), 949-957; DOI 10.1099/vir.0.18687-0

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© 2003 Society for General Microbiology

Heterogeneous Epstein–Barr virus latent gene expression in AIDS-associated lymphomas and in type I Burkitt's lymphoma cell lines

R. Touitou1, H. Arbach1, C. Cochet1, J. Feuillard2, A. Martin2, M. Raphaël2 and I. Joab1

1 INSERM EPI 03-34, IUH, Hôpital Saint-Louis, Paris, France
2 Hématologie Biologique, Hôpital Avicenne, EA 1625, UFR SMBH, Université Paris 13 Bobigny, France

Correspondence
Irène Joab
i.joab{at}chu-stlouis.fr

Epstein–Barr virus (EBV) is associated with lymphoma in immunocompromised patients. This study provides evidence that the expression of EBV nuclear antigen-3 genes can be directed from the F promoter in different type I Burkitt's lymphoma cell lines and in some lymphomas from human immunodeficiency virus-infected patients. This expression occurs predominantly after induction of the EBV lytic cycle.




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