| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Laboratory of Virology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy
2 Department of Pediatrics, University of Brescia, Italy
3 Pediatrics Unit, University of Siena, Italy
4 Epidemiologie Moleculaire des Enterovirus, Institut Pasteur, Paris, France
5 NIBSC, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK
Correspondence
Lucia Fiore
fiore{at}iss.it
The molecular and antigenic properties of a Sabin-like type 2 poliovirus, isolated from the stool samples of a 2-year-old agammaglobulinaemic child who developed paralysis 1 year after receiving the third dose of oral poliovirus vaccine, were analysed. The virus revealed 0·88 % genome variation in the VP1 region compared with the standard reference strain, compatible with replication of the virus in the intestine over approximately 1 year. The typical mutations in the 5'NCR and VP1 associated with reversion to neurovirulence for Sabin type 2 poliovirus were found. Despite this, the virus was characterized by both PCR and ELISA tests as Sabin-like and showed temperature sensitivity and neurovirulence in transgenic mice typical of the Sabin type 2 vaccine strain. Gammaglobulin replacement therapy led rapidly to virus clearance, which, when combined with treatment with the antiviral drug pleconaril, stopped virus excretion; no further virus shedding occurred. This is the first case of poliomyelitis and long-term excretion from an immunodeficient patient to be reported in Italy through the active ‘Acute Flaccid Paralysis' surveillance system.
This article has been cited by other articles:
|
|
 |
|
  S. Zurbriggen, K. Tobler, C. Abril, S. Diedrich, M. Ackermann, M. A. Pallansch, and A. Metzler Isolation of Sabin-Like Polioviruses from Wastewater in a Country Using Inactivated Polio Vaccine Appl. Envir. Microbiol., September 15, 2008; 74(18): 5608 - 5614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Dedepsidis, Z. Kyriakopoulou, V. Pliaka, C. Kottaridi, E. Bolanaki, S. Levidiotou-Stefanou, D. Komiotis, and P. Markoulatos Retrospective Characterization of a Vaccine-Derived Poliovirus Type 1 Isolate from Sewage in Greece Appl. Envir. Microbiol., November 1, 2007; 73(21): 6697 - 6704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-F. Yang, H.-Y. Chen, J. Jorba, H.-C. Sun, S.-J. Yang, H.-C. Lee, Y.-C. Huang, T.-Y. Lin, P.-J. Chen, H. Shimizu, et al. Intratypic Recombination among Lineages of Type 1 Vaccine-Derived Poliovirus Emerging during Chronic Infection of an Immunodeficient Patient J. Virol., October 15, 2005; 79(20): 12623 - 12634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Cherkasova, M. L. Yakovenko, G. V. Rezapkin, E. A. Korotkova, O. E. Ivanova, T. P. Eremeeva, L. I. Krasnoproshina, N. I. Romanenkova, N. R. Rozaeva, L. Sirota, et al. Spread of Vaccine-Derived Poliovirus from a Paralytic Case in an Immunodeficient Child: an Insight into the Natural Evolution of Oral Polio Vaccine J. Virol., January 15, 2005; 79(2): 1062 - 1070. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Martin, K. Odoom, G. Tuite, G. Dunn, N. Hopewell, G. Cooper, C. Fitzharris, K. Butler, W. W. Hall, and P. D. Minor Long-Term Excretion of Vaccine-Derived Poliovirus by a Healthy Child J. Virol., December 15, 2004; 78(24): 13839 - 13847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Blomqvist, C. Savolainen, P. Laine, P. Hirttio, E. Lamminsalo, E. Penttila, S. Joks, M. Roivainen, and T. Hovi Characterization of a Highly Evolved Vaccine-Derived Poliovirus Type 3 Isolated from Sewage in Estonia J. Virol., May 1, 2004; 78(9): 4876 - 4883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Korotkova, R. Park, E. A. Cherkasova, G. Y. Lipskaya, K. M. Chumakov, E. V. Feldman, O. M. Kew, and V. I. Agol Retrospective Analysis of a Local Cessation of Vaccination against Poliomyelitis: a Possible Scenario for the Future J. Virol., December 1, 2003; 77(23): 12460 - 12465. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
