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Genetic characterization of the unique short segment of Phocid herpesvirus type 1 reveals close relationships among alphaherpesviruses of hosts of the order Carnivora

¹ Seal Rehabilitation and Research Centre, Hoofdstraat 94a, 9968 AG Pieterburen, The Netherlands
² Central Laboratory, Federal State of Schleswig-Holstein, Max-Eyth-Str. 5, D-24537 Neumuenster, Germany
³ Erasmus MC, Institute of Virology, PO Box 1738, 3000 DR Rotterdam, The Netherlands

Correspondence
A. D. M. E. Osterhaus (at Erasmus MC)
osterhaus{at}viro.fgg.eur.nl

To further characterize phocid herpesvirus type 1 (PhHV-1) at the molecular level, a cluster of genes comprising the complete unique short (Us) region of PhHV-1 has been cloned and sequenced. Within this region, ORFs were detected that code for the equivalent of the Us 2- protein of herpes simplex virus (HSV), a putative protein kinase, and for the glycoprotein equivalents gG, gD, gI and gE. In addition, two small ORFs downstream of gE, homologous to the Us 8·5 and Us 9 proteins of HSV were identified. Comparative analysis of the ORF encoding the gD equivalent of PhHV-1 identified the corresponding proteins of the alphaherpesviruses canine herpesvirus and, to lesser degree, feline herpesvirus as the closest relatives.

Published ahead of print on 11 March 2003 as DOI 10.1099/vir.0.19005-0

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