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J Gen Virol 84 (2003), 1443-1450; DOI 10.1099/vir.0.19054-0

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© 2003 Society for General Microbiology

Updated Epstein–Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV

Orlando de Jesus1, Paul R. Smith1,{dagger}, Lindsay C. Spender1, Claudio Elgueta Karstegl1, Hans Helmut Niller2, Dolly Huang3 and Paul J. Farrell1

1 Ludwig Institute for Cancer Research, Faculty of Medicine, Imperial College, St Mary's Campus, Norfolk Place, London W2 1PG, UK
2 Institut für Medizinische Mikrobiologie und Hygiene, Universität Regensburg, D-93053 Regensburg, Germany
3 Department of Clinical Oncology, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region

Correspondence
Paul Farrell
p.farrell{at}imperial.ac.uk

Two sequences required for activity of the Epstein–Barr virus BART RNA promoter in transfection assays have been identified by site-directed mutagenesis. One contains a consensus AP-1 site; the other has some similarity to Ets and Stat consensus binding sites. Candidate sequences were suggested by mapping a region of unmethylated DNA in EBV around the BART promoter followed by in vivo footprinting the promoter in the C666-1 nasopharyngeal carcinoma cell line, which expresses BART RNAs. The data are presented in the context of a revised EBV DNA sequence, known as EBV wt, that is proposed as a future standard sequence for EBV.

{dagger}Present address: Department of Biology, Brunel University, Uxbridge, UK.




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