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J Gen Virol 84 (2003), 1781-1788; DOI 10.1099/vir.0.19088-0

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© 2003 Society for General Microbiology

Characterization of formaldehyde-inactivated poliovirus preparations made from live-attenuated strains

Javier Martín, Graham Crossland, David J. Wood and Philip D. Minor

Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire EN6 3QG, UK

Correspondence
Javier Martín
jmartin{at}nibsc.ac.uk

Formaldehyde-inactivated virus samples from type 1 poliovirus live-attenuated strains were prepared in the laboratory. The effect of treatment with formaldehyde on virus infectivity and immunogenicity in mice was investigated and the results compared with those from Mahoney wild-type poliovirus strain, the common type 1 component in commercial inactivated polio vaccines (IPV). Differences in the potency and specificity between these experimental vaccines were identified in both normal mice and transgenic mice expressing the human poliovirus receptor. The possible advantages/disadvantages of using live-attenuated strains for IPV production are discussed in the context of the global polio eradication initiative. A novel transgenic mouse model to study in vivo the immune protection induced by IPV preparations is described.

{dagger}Present address: Quality Assurance and Safety of Biologicals, World Health Organization, Avenue Appia 20, 1211 Geneva 27, Switzerland.






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