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1 Institute of Medical Microbiology and Immunology, University of Bonn, Sigmund-Freud Strasse 25, 53105 Bonn, Germany
2 Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Correspondence
Jean Ndjomou
ndjomou_j{at}hotmail.com
Hepatitis C virus (HCV) is a blood-borne pathogen that poses a significant threat to public health worldwide. The genetic diversity and distribution of HCV genotypes in non-Western countries, particularly subSaharan Africa, is poorly documented. This study reports a phylogenetic analysis of core and NS5B gene sequences of 37 HCV strains sampled in Cameroon. A high level of genetic diversity of both genotypes 1 and 4 was found, indicating a unique pattern of long-term HCV infection that has not been observed elsewhere. These results lead to the hypothesis that these HCV genotypes originated and diversified in west Central Africa before spreading to other regions.
The sequences reported in this study are deposited in GenBank under the following accession numbers: AY257069–AY257103 for the NS5B region and AY256784–AY256820 for the core region.
Present address: Department of Microbiology and Immunology, Indiana University School of Medicine, R2 302, 950 W. Walnut St. Indianapolis, IN 46202, USA.
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