HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Araibi, E. H. Articles by Campo, M. S. Search for Related Content PubMed PubMed Citation Articles by Araibi, E. H. Articles by Campo, M. S. Agricola Articles by Araibi, E. H. Articles by Campo, M. S.

Downregulation of major histocompatibility complex class I in bovine papillomas

Institute of Comparative Medicine, Division of Pathological Sciences, University of Glasgow, Garscube Estate, Glasgow G61 1QH, UK

Correspondence
M. S. Campo
s.campo{at}vet.gla.ac.uk

Bovine papillomavirus (BPV) induces papillomas in cattle; in the great majority of cases, these regress due to the host immune response, but they can persist and progress to malignancy. Even in the absence of malignant transformation, BPV infection persists for a significant period of time before activation of the host immune system, suggesting that the host immune system is unaware of, or disabled by, BPV. E5 is the major oncoprotein of BPV, which, in addition to its transforming properties, downregulates the expression and transport to the cell surface of major histocompatibility complex class I (MHC I). Here, it is shown that co-expression of MHC I and E5 in papillomas caused by BPV-4 infection is mutually exclusive, in agreement with the inhibition of surface MHC I expression by E5 that is observed in vitro. The inhibition of MHC expression in E5-expressing papilloma cells could explain the long period that is required for activation of the immune response and has implications for the progression of papillomas to the malignant stage; absence of peptide presentation by MHC I to cytotoxic T lymphocytes would allow the infected cells to evade the host cellular immune response and allow the lesions to persist.

This article has been cited by other articles:

				Z. Q. Yuan, L. Nicolson, B. Marchetti, E. A. Gault, M. S. Campo, and L. Nasir Transcriptional Changes Induced by Bovine Papillomavirus Type 1 in Equine Fibroblasts J. Virol., July 1, 2008; 82(13): 6481 - 6491. [Abstract] [Full Text] [PDF]

				G. H. Ashrafi, K. Piuko, F. Burden, Z. Yuan, E. A. Gault, M. Muller, A. Trawford, S. W. J. Reid, L. Nasir, and M. S. Campo Vaccination of sarcoid-bearing donkeys with chimeric virus-like particles of bovine papillomavirus type 1 J. Gen. Virol., January 1, 2008; 89(1): 148 - 157. [Abstract] [Full Text] [PDF]