| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Division of Host Genetics and Prion Diseases, National Microbiology Laboratory, Health Canada, Winnipeg, MB, Canada R3E 3R2
2 Institute for Biodiagnostics, National Research Council Canada, Winnipeg, MB, Canada R3B 1Y6
Correspondence
Stephanie Booth
Stephanie_Booth{at}hc-sc.gc.ca
Genes that are expressed differentially in the central nervous system of mice during infection with mouse-adapted scrapie agents were identified in this study. cDNA microarrays were used to examine gene-expression profiles at early, middle (preclinical) and late (clinical) time points after inoculation. A number of genes that showed significant changes in expression during the clinical stage of disease were identified. Of these, 138 were upregulated and 20 were downregulated. A smaller number of genes showed differential expression at the early and middle stages of the disease time course. These genes are interesting, as they may reflect biological processes that are involved in the molecular pathogenesis of the prion agent. At present, little is known about the early events in the disease process that trigger neurodegeneration. Perhaps most interestingly, one group of genes that exhibited decreased expression in all tested stages of the disease was identified in this study. This cluster included four transcripts representing haematopoietic system-related genes, which suggests that the haematopoietic system is involved in the disease process from an early stage.
Raw data and a hyperlinked version of Table 1 are available as supplementary material in JGV Online.
This article has been cited by other articles:
|
|
 |
|
  C. Bach, S. Gilch, R. Rost, A. D. Greenwood, M. Horsch, G. N. M. Hajj, S. Brodesser, A. Facius, S. Schadler, K. Sandhoff, et al. Prion-induced Activation of Cholesterogenic Gene Expression by Srebp2 in Neuronal Cells J. Biol. Chem., November 6, 2009; 284(45): 31260 - 31269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gersten, M. Alirezaei, M. C. G. Marcondes, C. Flynn, T. Ravasi, T. Ideker, and H. S. Fox An Integrated Systems Analysis Implicates EGR1 Downregulation in Simian Immunodeficiency Virus Encephalitis-Induced Neural Dysfunction J. Neurosci., October 7, 2009; 29(40): 12467 - 12476. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tang, W. Xiang, S. A. C. Hawkins, H. A. Kretzschmar, and O. Windl Transcriptional Changes in the Brains of Cattle Orally Infected with the Bovine Spongiform Encephalopathy Agent Precede Detection of Infectivity J. Virol., September 15, 2009; 83(18): 9464 - 9473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. P. Sawiris, K. G. Becker, E. J. Elliott, R. Moulden, and R. G. Rohwer Molecular analysis of bovine spongiform encephalopathy infection by cDNA arrays J. Gen. Virol., April 1, 2007; 88(4): 1356 - 1362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Saha, P. Sugumar, P. Bhandari, and P. N. Rangarajan Identification of Japanese encephalitis virus-inducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein. J. Gen. Virol., November 1, 2006; 87(Pt 11): 3285 - 3289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Saha, S. Murthy, and P. N. Rangarajan Identification and characterization of a virus-inducible non-coding RNA in mouse brain J. Gen. Virol., July 1, 2006; 87(7): 1991 - 1995. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
