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1 Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
2 Department of Developmental Medical Sciences, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
3 Department of Gastroentero-Hepatology, Cho Ray Hospital, Ho Chi Minh City, Vietnam
4 Department of Hepatology, Yangon General Hospital, Yangon, Myanmar
5 Department of Gastroenterology, Mahidol University Siriraj Hospital, Bangkok, Thailand
6 Gastroenterology Section, Okinawa Chubu Hospital, Okinawa, Japan
Correspondence
Kenji Abe
kenjiabe{at}nih.go.jp
A genomic characterization of hepatitis B virus (HBV) was done for 56 pre-S1/pre-S2 genes and 10 full-length HBV genotype C isolates from five Asian countries. Phylogenetic analysis of the pre-S1/pre-S2 genes revealed two major groups within genotype C: one for isolates from southeast Asia including Vietnam, Myanmar and Thailand (named HBV/C1) and the other for isolates from Far East Asia including Japan, Korea and China (named HBV/C2). This finding was confirmed by phylogenetic analysis based on the full-length sequence of 32 HBV genotype C isolates, including 22 from database entries. Two isolates from Okinawa, the island off the southern end of Japan, formed a different branch. Specific amino acid sequence changes were identified in the large S protein (amino acids 51, 54, 60, 62 and 73) and P protein (amino acids 231, 233, 236, 248, 252 and 304). Our results indicate that genotype C of HBV can be classified into at least two subgroups.
The DDBJ/GenBank/EMBL accession nos. of sequences reported in this study are HBV-VT101, AB112063; HBV-VT103, AB111946; HBV-VT140, AB112065; HBV-MY624, AB112066; HBV-MY656, AB112348; HBV-MY683, AB112408; HBV-TH123, AB112471; HBV-TH124, AB112472; HBV-O47, AB115417; and HBV-O55, AB115418.
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