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J Gen Virol 85 (2004), 609-613; DOI 10.1099/vir.0.19760-0

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© 2004 Society for General Microbiology

Short Communication

Vaccine potential of a murine gammaherpesvirus-68 mutant deficient for ORF73

Polly Fowler and Stacey Efstathiou

Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK

Correspondence
Stacey Efstathiou
se{at}mole.bio.cam.ac.uk

A murine gammaherpesvirus (MHV-68) containing a deletion of the putative plasmid maintenance protein ORF73 exhibits a severe latency deficit. In this study the ability of an ORF73 deletion mutant ({Delta}73) to confer in vivo protection against subsequent challenge with wild-type virus has been examined. Vaccination studies have shown that {Delta}73 vaccination reduced latent infection of wild-type challenge virus to a level below the limit of detection. These results indicate that a live-attenuated gammaherpesvirus that cannot persist is an effective vaccine.




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