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The central region of human immunodeficiency virus type 1 p6 protein (Gag residues S14–I31) is dispensable for the virus in vitro

¹ Division of Infectious Diseases, University of Lausanne, Lausanne, Switzerland
² Institute of Microbiology, University of Lausanne, Lausanne, Switzerland
³ University Hospital, and Center of Electron Microscopy, University of Lausanne, Lausanne, Switzerland

Correspondence
Amalio Telenti
amalio.telenti{at}hospvd.ch

The human immunodeficiency virus type 1 p6 region encodes p6^Gag and the transframe p6^Pol protein. The Gag frame encodes an N-terminal late assembly L domain and a C-terminal Vpr binding domain. In the Pol frame, substitution at a C-terminal motif decreases protease autocleavage. The role of the highly polymorphic central region of p6, comprising amino acids S14–I31 (p6^Gag) and R20–D39 (p6^Pol), is unclear. Analysis of this central region demonstrated that 35 % of p6^Gag appears to be dispensable for virus propagation in vitro and smaller deletion and insertion polymorphisms can be tolerated in vivo. Extensive Pol deletion (R20–D39, 42 % of p6^Pol) did not alter protease autocleavage.

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